Tengfei Bian

Tengfei Bian, Ph.D.

Assistant Scientist

Department: Medicinal Chemistry
Business Phone: (352) 215-0604
Business Email: tbian@ufl.edu

About Tengfei Bian

Dr. Bian has built research expertise in cancer biology, medicinal chemistry, and molecular and cellular biology. During his time as apostdoctoral associate, Bian has spent years investigating the effects of chronic stress and cigarette smoking on lung cancer progression and understanding the molecular mechanisms. Bian found that NNAL can deactivate LKB1 through phosphorylation in lung cancer cells and a xenograft mouse model through the activation of the β-adrenergic receptor (AR) and PKA pathway. His findings suggest that such a deactivation may be of great clinical relevance given the tumor-suppressive functions of LKB1 in lung cancer initiation, development and progression as well as the association between the lung cancer patient clinical outcome and the loss of LKB1 function. This important work was published in Oncogene in 2022. He is also working on characterizing the phosphorylation of LKB1 induced by stress hormones and characterizing bioactive small molecule natural products to rescue the function of LKB1 through suppressing the β-AR and PKA pathway. His manuscripts highlight his efforts in cigarette smoking and LKB1 de-activation in lung cancer progression. His sponsor, Dr. Chengguo Xing, is a recognized leader in the medicinal chemistry and cancer biology field and has trained many postdoctoral fellows that have moved on to have successful careers.

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-4029-2576

Publications

2023
Investigating miR-9 as a mediator in laryngeal cancer health disparities.
Frontiers in oncology. 13 [DOI] 10.3389/fonc.2023.1096882. [PMID] 37081981.
2023
Opportunities and Challenges of Kava in Lung Cancer Prevention
International Journal of Molecular Sciences. 24(11) [DOI] 10.3390/ijms24119539. [PMID] 37298489.
2022
Combined physiological and transcriptome analysis revealed the response mechanism of Pogostemon cablin roots to p-hydroxybenzoic acid.
Frontiers in plant science. 13 [DOI] 10.3389/fpls.2022.980745. [PMID] 36226287.
2022
LKB1 phosphorylation and deactivation in lung cancer by NNAL, a metabolite of tobacco-specific carcinogen, in an isomer-dependent manner
Oncogene. 41(33):4042-4054 [DOI] 10.1038/s41388-022-02410-x.
2022
Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming-A New Mechanism for SCLC Chemoresistance Boosted by Nicotine.
Cancers. 14(9) [DOI] 10.3390/cancers14092272. [PMID] 35565402.
2022
Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis.
Carcinogenesis. 43(7):659-670 [DOI] 10.1093/carcin/bgac031. [PMID] 35353881.
2020
CXL146, a Novel 4H-Chromene Derivative, Targets GRP78 to Selectively Eliminate Multidrug-Resistant Cancer Cells.
Molecular pharmacology. 97(6):402-408 [DOI] 10.1124/mol.119.118745. [PMID] 32276963.
2020
Erratum: Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells.
Planta medica. 86(1) [DOI] 10.1055/a-1158-2228. [PMID] 32316039.
2020
Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells.
Planta medica. 86(1):26-31 [DOI] 10.1055/a-1035-5183. [PMID] 31711251.
2020
Kava as a Clinical Nutrient: Promises and Challenges.
Nutrients. 12(10) [DOI] 10.3390/nu12103044. [PMID] 33027883.
2019
Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.
Journal of medicinal chemistry. 62(12):5750-5772 [DOI] 10.1021/acs.jmedchem.8b01668. [PMID] 30676015.
2018
An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules.
Molecular pharmaceutics. 15(9):3892-3900 [DOI] 10.1021/acs.molpharmaceut.8b00359. [PMID] 30048137.
2018
Exploring the Structure-Activity Relationship and Mechanism of a Chromene Scaffold (CXL Series) for Its Selective Antiproliferative Activity toward Multidrug-Resistant Cancer Cells.
Journal of medicinal chemistry. 61(15):6892-6903 [DOI] 10.1021/acs.jmedchem.8b00813. [PMID] 29995404.
2016
Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.
Biochemical and biophysical research communications. 481(3-4):206-211 [DOI] 10.1016/j.bbrc.2016.10.096. [PMID] 27815070.

Contact Details

Phones:
Business:
(352) 215-0604
Emails:
Business:
tbian@ufl.edu
Addresses:
Business Mailing:
PO Box 100485
GAINESVILLE FL 32610
Business Street:
1345 CENTER DR
GAINESVILLE FL 32610