Raymond J Bergeron, Jr

Raymond J Bergeron, Jr

Eminent Scholar

Department: Medicinal Chemistry
Business Phone: (352) 273-7725
Business Email: rayb@ufl.edu

Publications

2020 Metabolism: clinical and experimental
2015 Bioorganic & medicinal chemistry
2011 Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
2009 International journal of radiation biology
2009 Journal of medicinal chemistry
2008 Journal of medicinal chemistry
2005 Journal of medicinal chemistry
2005 Journal of medicinal chemistry
2003 Journal of medicinal chemistry
2002 Toxicological sciences : an official journal of the Society of Toxicology
2002 Advances in experimental medicine and biology
1999 Drug metabolism and disposition: the biological fate of chemicals
1998 Pharmacological research
1997 The Journal of organic chemistry
1996 Drug metabolism and disposition: the biological fate of chemicals
1995 Journal of medicinal chemistry
1995 Journal of medicinal chemistry
1995 Drug metabolism and disposition: the biological fate of chemicals
1995 Clinical cancer research : an official journal of the American Association for Cancer Research
1995 Clinical and experimental hypertension (New York, N.Y. : 1993)
1994 Journal of medicinal chemistry
1994 International journal of radiation oncology, biology, physics
1994 Journal of medicinal chemistry
1990 Annals of the New York Academy of Sciences
1988 Biochemical and biophysical research communications
1988 Journal of medicinal chemistry
1984 Biochemical and biophysical research communications

Grants

Mar 2010 – May 2016
Iron Chelators Predicated on Desferrithiocin.
NATL INST OF HLTH NIDDK · Principal Investigator

Patents

Issued March 1985
Methods and Intermediates for the Preparation of Spermidine, Homospermidine and Norspermidine Hydrogenation of Azadinitriles
#4,505,861
Issued January 1986
Synthesis of Parabactin and Homologs Thereof Iron Overload Syndromes
#4,565,874
Issued January 1991
Method for the Synthesis of Desferrioxamine B and Analogs Thereof Multicondensations and Reductions, Starting with a Cyanoalkanal And an Hydroxylamine Derivative
#4,987,253
Issued February 1992
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Antipsoriasis, Insecticides (CIP)
#5,091,576
Issued July 1992
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Parabactin or Derivative
#5,128,353
Issued December 1992
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Antimalarial Agents
#5,173,505
Issued October 1993
Method for Synthesis of Desferrioxamine B, Analogs and Homologs Thereof
#5,254,724
Issued March 1994
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,292,775
Issued June 1994
Analogs of Desferrioxamine B and Method for Synthesis Thereof Deblocking, Condensation, Alkylation, Acrylation, Reduction
#5,322,961
Issued August 1994
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Bis-hexahydropyrimidinylakyl Compounds (DIV)
#5,342,945
Issued November 1994
Analogs of Desferrioxamine B and Method for Synthesis Thereof Treatment Of Thalassemia (DIV)
#5,364,965
Issued November 1994
Method for Synthesis of Desferrioxamine B, Analogs and Homologs Thereof Iron Chelate Compounds with Polyether Derivatives
#5,367,113
Issued February 1995
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Specific Iron Chelator
#5,391,563
Issued February 1995
Polyamines and Anti-diarrheal and Gastrointestinal Anti-spasmodic Pharmaceutical Compositions and Methods of Treatment (CIP)
#5,393,757
Issued October 1995
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives
#5,455,277
Issued October 1995
Polyamines and Anti-diarrheal and Gastrointestinal Anti-spasmodic Pharmaceutical Compositions and Methods of Treatment
#5,462,970
Issued November 1995
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,466,702
Issued February 1996
Method for Preparing Desferrioxamine B and Homologs Thereof N-benzyloxy-1,5-diaminopentane Selectively Protected at Primary Amine Site Reacted with Anhydride to Produce Carboxylic Acid, Acylation, Reacting with Diamine, Hydrogenolysis, Deprotecting
#5,493,053
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,838
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,840
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,839
Issued March 1996
Anti-neoplastic Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,837
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Method of Treatment Treatment Of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives With Catechol
#5,496,841
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment an Iron Chelator, Malaria
#5,498,622
Issued April 1996
Anti-hypertensive Composition and Methods of Treatment Administering Polyalkylene-amines or Salts Thereof
#5,510,390
Issued May 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Psoriasis
#5,514,695
Issued May 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Anticarcinogenic Agents from Polyamide Derivatives
#5,519,041
Issued July 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,536,738
Issued July 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,536,739
Issued July 1996
Anti-neoplastic Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,541,207
Issued August 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering to Human or Animal Effective Amount to Parabactin or Salts to Inhibit Proliferation of Malignant Cells
#5,545,649
Issued August 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering to Human or Animal Effective Amount to Parabactin or Salts to Inhibit Proliferation of Malignant Cells; Antileukemia Agent
#5,545,650
Issued August 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Iron Chelating Agent to Treat Psoriasis
#5,550,144
Issued October 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Vibriobactin or Parabactin to Inhibit Proliferation of Malignant Cells by Complexing Iron to Interfere with Their Mechanism for Iron Acquisition
#5,569,666
Issued August 1997
Sterically Hindered Tetraamines and Method for Their Production Insecticides, Pharmaceuticals
#5,656,671
Issued October 1997
Polyamines and Anti-diarrheal and Gastrointestinal Anti-spasmodic Pharmaceutical Compositions and Methods of Treatment
#5,677,352
Issued October 1997
Sterically Hindered Tetraamines and Method for Their Production Administering Anti-diarrhea, Anti-peristaltic or Gastrointestinal Anti-spasmodic Agent08/
#5,677,351
Issued October 1997
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Administering Spermine Derivative; Mosquito Growth Controller (DIV)
#5,679,682
Issued October 1997
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Mosquito Insecticidal Composition
#5,681,837
Issued April 1998
Method for Synthesis of Rhizoferrin
#5,739,395
Issued October 1998
Anti-Neoplastic, Anti-Viral or Anti-retroviral Spermine Derivatives
#5,827,894
Issued November 1998
Thiazoline Acid Derivatives
#5,840,739
Issued December 1998
Methods and Bicyclic Polyamine Compositions for the Tretament of Inflammation
#5,843,959
Issued February 1999
Anti-Neoplastic, Anti-Viral or Anti-Retroviral Spermine Derivatives.
#5,866,613
Issued March 1999
Sterically Hindered Tetramines & Method for their Production
#5,886,050
Issued March 1999
Methods and Compositions for the Treatment of Cerebro-Neurodegeneration
#5,886,051
Issued October 1999
Hydroxy Polyamines
#5,962,533
Issued October 1999
Hypusine Reagent for Peptide Synthesis
#5,973,113
Issued March 2000
Anti-Neoplastic, Anti-Viral or Anti Retroviral Spermine Derivatives
#6,034,139
Issued July 2000
Thiazoline Acid Derivatives
#6,083,966
Issued July 2000
Anti-Arrhythmic Composition And Methods of Treatment
#6,083,991
Issued November 2000
Anti-Neoplastic, Anti-Viral or Anti-Retroviral Spermine Derivatives
#6,147,262
Issued December 2000
Method and Composition for Treatment of Inflammatory Bowel Disease
#6,159,983
Issued December 2000
Chemical Resection of Pancreas
#6,160,022
Published December 2000
N,N'-BIS(2-Hydroxy Benzyl) Ethylenediamine-N,N'-Diacetic Acid in Iron Chelating Therapy
#2001-0039295 A1
Issued February 2001
Analogs of Biologically Active Naturally Occurring Polyamines Pharmaceutical Composition and Methods of Treatment. (CIP)
#6,184,232
Issued May 2001
Triamines based on Invention Disclosure titled A Metabolically Programmed Polyamine Analogue Antidiarrheals
#6,235,794
Issued June 2001
N, N'-BIS(2-Hydroxybenzyl) Ethylenediamine-N, N'-Diacetic Acid In Iron Chelating Therapy (CIP) UF#1821
#6,242,492
Issued June 2001
Hypusine Reagent For Peptide Synthesis
#6,248,866
Issued July 2001
Deoxyhypusine Reagent And Peptides Synthesis
#6,258,931
Issued July 2001
Sterically Hindered Tetramines & Method for Their Production
#6,262,125
Issued August 2001
Method of Inhibiting Biosynthesis of EIf5A
#6,274,630
Issued October 2001
Anti-Arrhythmic Composition and Methods of Treatment (CON)
#6,297,287
Issued January 2002
Analogs of Biologically Active, Naturally Occurring Polyamines Pharmaceutical Compositions and Methods of Treatment (CON)
#6,342,534
Published March 2002
Method and Composition for the Treatment of Diarrhea and Gastrointestinal Spasms (CON)
#US-2002-0193408-A1
Issued March 2002
Anti-Neoplastic Anti-Viral or Anti-Removal Spermine Derivatives (CON)
#6,362,232
Issued June 2002
Method and Composition for the Treatment of Diarrhea and Gastrointestinal Spasms.
#6,399,662
Published August 2002
Antioxidant and Free Radical Scavenging Compositions
#US-2004-0044220-A1
Issued September 2002
Polyamines and Anti-Diarrheal and Gastrointestinal Anti-Spasmodic Pharmaceutical Compositions and Methods of Treatment (DIV)
#6,455,591
Issued October 2002
Methods and Compositions (polyamines) for the Treatment of Diarrhea-predominant Irritable Bowel Syndrome.
#6,458,795
Issued October 2002
Sterically Hindered Tetramines & Method for Their Production (CIP)
#6,472,426
Published November 2002
Thiazoline Acid Derivatives
#US-2003-0236417-A1
Issued December 2002
Hypusine Peptides
#6,492,491
Issued December 2002
Hypusine Peptides (CON)
#6,492,489
Issued February 2003
Thiazoline Acid Derivatives (CON)
#6,521,652
Issued February 2003
Thiazoline Acid Derivatives (CON)
#6,525,080
Issued March 2003
N,N'-BIS(2-Hydroxybenzyl) Ethylenediamine-N,N'-Diacetic Acid in Iron Chelating Therapy (CON)
#6,531,510
Issued May 2003
Thiazoline Acid Derivataives (CON)
#6,559,315
Published August 2003
Antioxidant and Radical Scavenging Activity of Synthetic Analogs of Desferrithiocin (CON)
#2004-0132789-A1
Issued November 2003
Method for Making HBED (owned by Genzyme)
#6,646,157
Issued December 2003
Method and Composition for Treatment of Irritable Bowel Disease (DIV)
#6,664,270
Issued February 2004
Anti-Neoplastic, Anti-Viral or Anti-Retroviral Spermine Derivatives
#RE38,417 E
Issued February 2004
Method and Composition of Treatment of Inflammatory Bowel Disease.
#6,689,788
Issued November 2004
Method and Composition for Treatment of Irritable Bowel Disease
#6,818,656
Issued January 2005
Anti-Hypertensive Composition and Methods of Treatment (CON)
#6,841,576
Published January 2005
Antioxidant and Radical Scavenging Activity of Synthetic Analogs of Desferrithiocin (CON) (Abandoned in favor of 12/079,596 CON)
#20050234113
Published January 2005
Compositions and Methods for Inhibiting Pain
#2006-0160905-A1
Issued March 2005
Iron Binding Agents
#6,864,270
Published March 2006
Polyamine-Iron Chelator Conjugate (CON)
#2008/0096974 A2
Issued June 2006
Thiazoline Acid Derivatives -(Reissue)
#RE39132
Issued August 2006
Analogs of Biologially Active, Naturally Occuring Polyamines, Pharmaceutical Compositions and Methods of Treatment
#7,094,808
Published October 2006
Methods of Treating Hepatocellular Carcinoma With Denspm
#2007-0167528
Issued October 2006
Thiazoline Acid Derivatives (CON)
#7,126,004
Issued December 2006
Iron Binding Agents (CON)
#7,144,904
Published December 2007
Chemical Resection of Pancreas (CON)
#2008-0108706-A1
Issued September 2008
Aminopolyamine Sample Pharmacophores
#7,423,182
Issued May 2009
Thiazoline Acid Derivatives (CON)
#7,531,563
Published June 2009
Desferrithiocin Analogue Actinide Decorporation Agents
#US 2010-0137346 A1
Issued April 2010
Anti-Hypertensive Composition and Methods of Treatment (DIV)
#7,691,684
Issued February 2011
Iron Binding Agents (CON)
#7,879,886
Issued August 2011
Thiazoline Acid Derivatives (CON)
#8,008,502
Published November 2011
Hydroxypolyomine Salts
#US-2013-0137772-A1
Published March 2012
Desferrithiocin Polyether Analogues and Uses Thereof
#US-2012-0184586-A1
Issued October 2012
Desferrithiocin Polyether Analogues
#8,278,458
Issued December 2012
Desferrithiocin Polyether Analogues
#8,324,397
Issued December 2013
Desferrithiocin Derivatives and Methods of Use Thereof
#8,604,216
Issued May 2014
Desferrithiocin Polyether Analogues
#8,722,899
Published June 2014
Uses of 3'-Desferrithiocin Analogs
#US-2014-0323534-A1
Issued September 2014
Siderophore Conjugate Immunogenic Compositions and Vaccines
#8,834,890
Issued August 2015
Desferrithiocin Polyether Analogues (CON of 11713)
#9,096,553
Issued September 2015
Siderophore Conjugate Immunogenic Compositions and Vaccines (DIV of 13133)
#9,125,950
Issued November 2015
Desferrithiocin Polyether Analogues (CON of UF#12096)
#9,174,948
Issued February 2017
Desferrithiocin Polyether Analogues (DIV of 15181)
#9,567,309
Published June 2017
Use of HBED in Hemorrhagic Stroke and Closed Head Injury
#US-2018-0161295-A1
Published August 2017
Dosing Regimens for Treating Metal-Mediated Conditions
#US-2018-0036228-A1
Issued August 2017
Desferrithiocin Polyether Analogues
#9,730,917
Published October 2017
Metabolically Programmed Metal Chelators and Uses Thereof
#US-2018-0140581
Published June 2018
Desferrithiocin Polyether Analogues (CON of 16590 (DIV of 15866)(11713)
#US 2019-0290990 A1
Issued June 2018
Desferrithiocin Polyether Analogues (DIV of 15866)
#9,994,535
Issued July 2018
Desferrithiocin Analogs and Uses Thereof
#10,010,535

Contact Details

Phones:
Business:
(352) 273-7725
Emails:
Business:
rayb@ufl.edu