Raymond J Bergeron

Raymond J Bergeron,

Eminent Scholar

Department: Medicinal Chemistry
Business Phone: (352) 273-7725
Business Email: rayb@ufl.edu

Publications

2020
Targeting pheochromocytoma/paraganglioma with polyamine inhibitors.
Metabolism: clinical and experimental. 110 [DOI] 10.1016/j.metabol.2020.154297. [PMID] 32562798.
2015
Metabolically programmed iron chelators.
Bioorganic & medicinal chemistry. 23(17):5954-71 [DOI] 10.1016/j.bmc.2015.06.059. [PMID] 26231739.
2014
Desferrithiocin: a search for clinically effective iron chelators.
Journal of medicinal chemistry. 57(22):9259-91 [DOI] 10.1021/jm500828f. [PMID] 25207964.
2012
Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles.
Journal of medicinal chemistry. 55(16):7090-103 [DOI] 10.1021/jm300509y. [PMID] 22889170.
2011
Desferrithiocin analogue iron chelators: iron clearing efficiency, tissue distribution, and renal toxicity.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 24(2):239-58 [DOI] 10.1007/s10534-010-9389-y. [PMID] 21103911.
2011
Synthesis of Heterobactins A and B and Nocardia Heterobactin.
Tetrahedron. 67(18):3163-3169 [PMID] 22539866.
View on: PubMed
2010
Design, Synthesis, and Testing of Polyamine Vectored Iron Chelators.
Synthesis. 2010(21):3631-3636 [PMID] 22013282.
View on: PubMed
2010
The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues.
Journal of medicinal chemistry. 53(7):2843-53 [DOI] 10.1021/jm9018146. [PMID] 20232803.
2009
Desferrithiocin analogue uranium decorporation agents.
International journal of radiation biology. 85(4):348-61 [DOI] 10.1080/09553000902781089. [PMID] 19399680.
2009
Vibriobactin antibodies: a vaccine strategy.
Journal of medicinal chemistry. 52(12):3801-13 [DOI] 10.1021/jm900119q. [PMID] 19492834.
2008
Desferrithiocin analogues and nephrotoxicity.
Journal of medicinal chemistry. 51(19):5993-6004 [DOI] 10.1021/jm8003398. [PMID] 18788724.
2008
Design, synthesis, and testing of non-nephrotoxic desazadesferrithiocin polyether analogues.
Journal of medicinal chemistry. 51(13):3913-23 [DOI] 10.1021/jm800154m. [PMID] 18533709.
2008
Medi 296-Bacterial Siderophore: New Versatile Synthesis and Stoichiometry of Vulnibactin
. 235
2008
Neurobiological and Clinical Effects of Combining Two Antidepressant Medications From the Start
International Journal of Neuropsychopharmacology. 11:9-10
2007
Impact of the 3,6,9-trioxadecyloxy group on desazadesferrithiocin analogue iron clearance and organ distribution.
Journal of medicinal chemistry. 50(14):3302-13 [PMID] 17564424.
View on: PubMed
2006
(S)-4,5-dihydro-2-(2-hydroxy-4-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid polyethers: a solution to nephrotoxicity.
Journal of medicinal chemistry. 49(9):2772-83 [PMID] 16640338.
View on: PubMed
2006
The design, synthesis, and evaluation of organ-specific iron chelators.
Journal of medicinal chemistry. 49(24):7032-43 [PMID] 17125256.
View on: PubMed
2005
Partition-variant desferrithiocin analogues: organ targeting and increased iron clearance.
Journal of medicinal chemistry. 48(3):821-31 [PMID] 15689166.
View on: PubMed
2005
Polyamine-vectored iron chelators: the role of charge.
Journal of medicinal chemistry. 48(12):4120-37 [PMID] 15943485.
View on: PubMed
2005
Synthesis and biological evaluation of aminopolyamines.
Journal of medicinal chemistry. 48(9):3099-102 [PMID] 15857111.
View on: PubMed
2004
Comparison of iron chelator efficacy in iron-overloaded beagle dogs and monkeys (Cebus apella).
Comparative medicine. 54(6):664-72 [PMID] 15679265.
View on: PubMed
2003
Desferrithiocin analogue based hexacoordinate iron(III) chelators.
Journal of medicinal chemistry. 46(1):16-24 [PMID] 12502356.
View on: PubMed
2003
Iron chelation promoted by desazadesferrithiocin analogs: An enantioselective barrier.
Chirality. 15(7):593-9 [PMID] 12840823.
View on: PubMed
2003
Methoxylation of desazadesferrithiocin analogues: enhanced iron clearing efficiency.
Journal of medicinal chemistry. 46(8):1470-7 [PMID] 12672247.
View on: PubMed
2003
Polyamine-iron chelator conjugate.
Journal of medicinal chemistry. 46(25):5478-83 [PMID] 14640556.
View on: PubMed
2003
Prevention of acetic acid-induced colitis by desferrithiocin analogs in a rat model.
Digestive diseases and sciences. 48(2):399-407 [PMID] 12643622.
View on: PubMed
2002
HBED ligand: preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning.
Blood. 99(8):3019-26 [PMID] 11929795.
View on: PubMed
2002
Measurement of arsenic bioavailability in soil using a primate model.
Toxicological sciences : an official journal of the Society of Toxicology. 67(2):303-10 [PMID] 12011490.
View on: PubMed
2002
Structure-activity relationships among desazadesferrithiocin analogues.
Advances in experimental medicine and biology. 509:167-84 [PMID] 12572994.
View on: PubMed
2001
Control of irritable bowel syndrome with polyamine analogs: a structure-activity study.
Digestive diseases and sciences. 46(12):2615-23 [PMID] 11768250.
View on: PubMed
2001
Polyamine analogue antidiarrheals: a structure-activity study.
Journal of medicinal chemistry. 44(2):232-44 [PMID] 11170633.
View on: PubMed
2001
Significance of asymmetric sites in choosing siderophores as deferration agents.
Journal of medicinal chemistry. 44(15):2469-78 [PMID] 11448229.
View on: PubMed
2001
Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives.
Journal of medicinal chemistry. 44(15):2451-9 [PMID] 11448227.
View on: PubMed
2000
Metabolism and pharmacokinetics of N1,N11-diethylnorspermine in a Cebus apella primate model.
Cancer research. 60(16):4433-9 [PMID] 10969789.
View on: PubMed
2000
Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives.
Journal of medicinal chemistry. 43(2):224-35 [PMID] 10649978.
View on: PubMed
1999
Desazadesmethyldesferrithiocin analogues as orally effective iron chelators.
Journal of medicinal chemistry. 42(1):95-108 [PMID] 9888836.
View on: PubMed
1999
Effects of C-4 stereochemistry and C-4′ hydroxylation on the iron clearing efficiency and toxicity of desferrithiocin analogues.
Journal of medicinal chemistry. 42(13):2432-40 [PMID] 10395484.
View on: PubMed
1999
Evaluation of the desferrithiocin pharmacophore as a vector for hydroxamates.
Journal of medicinal chemistry. 42(15):2881-6 [PMID] 10425097.
View on: PubMed
1999
HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy.
Blood. 93(1):370-5 [PMID] 9864183.
View on: PubMed
1999
Pharmacokinetics of orally administered desferrithiocin analogs in cebus apella primates.
Drug metabolism and disposition: the biological fate of chemicals. 27(12):1496-8 [PMID] 10570032.
View on: PubMed
1999
Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells.
Cancer research. 59(6):1278-86 [PMID] 10096560.
View on: PubMed
1998
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Journal of medicinal chemistry. 41(20):3901-8 [PMID] 9748365.
View on: PubMed
1998
HBED: A potential alternative to deferoxamine for iron-chelating therapy.
Blood. 91(4):1446-52 [PMID] 9454776.
View on: PubMed
1998
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors.
The Prostate. 34(1):51-60 [PMID] 9428388.
View on: PubMed
1998
Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664.
Cancer research. 58(17):3883-90 [PMID] 9731498.
View on: PubMed
1998
Polyamine analogue antiarrhythmics.
Pharmacological research. 38(5):367-80 [PMID] 9806817.
View on: PubMed
1998
Synthesis of reagents for the construction of hypusine and deoxyhypusine peptides and their application as peptidic antigens.
Journal of medicinal chemistry. 41(20):3888-900 [PMID] 9748364.
View on: PubMed
1998
The origin of the differences in (R)- and (S)-desmethyldesferrithiocin. Iron-clearing properties.
Annals of the New York Academy of Sciences. 850:202-16 [PMID] 9668541.
View on: PubMed
1997
A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics.
Journal of medicinal chemistry. 40(10):1475-94 [PMID] 9154970.
View on: PubMed
1997
Development of a Hypusine Reagent for Peptide Synthesis.
The Journal of organic chemistry. 62(10):3285-3290 [PMID] 11671715.
View on: PubMed
1997
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.
Cancer research. 57(24):5521-7 [PMID] 9407962.
View on: PubMed
1997
Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs.
Molecular pharmacology. 52(1):69-74 [PMID] 9224814.
View on: PubMed
1997
The influence of molecular conformation upon the self-assembly of cyclohexane diamide diacids.
Bioorganic & medicinal chemistry. 5(11):2049-61 [PMID] 9416422.
View on: PubMed
1996
Metabolically programmed polyamine analogue antidiarrheals.
Journal of medicinal chemistry. 39(13):2461-71 [PMID] 8691443.
View on: PubMed
1996
Metabolism and pharmacokinetics of N1,N14-diethylhomospermine.
Drug metabolism and disposition: the biological fate of chemicals. 24(3):334-43 [PMID] 8820425.
View on: PubMed
1996
Polyamine analogue regulation of NMDA MK-801 binding: a structure-activity study.
Journal of medicinal chemistry. 39(26):5257-66 [PMID] 8978854.
View on: PubMed
1996
Synthesis and biological evaluation of naphthyldesferrithiocin iron chelators.
Journal of medicinal chemistry. 39(8):1575-81 [PMID] 8648596.
View on: PubMed
1995
Impact of polyamine analogues on the NMDA receptor.
Journal of medicinal chemistry. 38(3):425-8 [PMID] 7853334.
View on: PubMed
1995
Metabolism and pharmacokinetics of N1,N11-diethylnorspermine.
Drug metabolism and disposition: the biological fate of chemicals. 23(10):1117-25 [PMID] 8654201.
View on: PubMed
1995
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
Clinical cancer research : an official journal of the American Association for Cancer Research. 1(8):847-57 [PMID] 9816054.
View on: PubMed
1995
The impact of polyamine analogues on the blood pressure of normotensive and hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993). 17(8):1197-217 [PMID] 8563697.
View on: PubMed
1995
The role of charge in polyamine analogue recognition.
Journal of medicinal chemistry. 38(13):2278-85 [PMID] 7608892.
View on: PubMed
1994
An investigation of desferrithiocin metabolism.
Journal of medicinal chemistry. 37(18):2889-95 [PMID] 8071936.
View on: PubMed
1994
Antiproliferative properties of polyamine analogues: a structure-activity study.
Journal of medicinal chemistry. 37(21):3464-76 [PMID] 7932575.
View on: PubMed
1994
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.
Cancer research. 54(22):5917-24 [PMID] 7954423.
View on: PubMed
1994
Design and testing of novel cytotoxic polyamine analogues.
Cancer research. 54(23):6210-4 [PMID] 7954468.
View on: PubMed
1994
Radiopotentiation of human brain tumor cells by the spermine analog N1,N14-bis(ethyl)homospermine.
International journal of radiation oncology, biology, physics. 29(5):1041-7 [PMID] 8083073.
View on: PubMed
1994
The desferrithiocin pharmacophore.
Journal of medicinal chemistry. 37(10):1411-7 [PMID] 8182699.
View on: PubMed
1993
A comparative study of the iron-clearing properties of desferrithiocin analogues with desferrioxamine B in a Cebus monkey model.
Blood. 81(8):2166-73 [PMID] 8471775.
View on: PubMed
1993
Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
Cancer research. 53(3):581-6 [PMID] 8425191.
View on: PubMed
1993
Effects of diethyl spermine analogues in human bladder cancer cell lines in culture.
The Journal of urology. 150(4):1293-7 [PMID] 8371417.
View on: PubMed
1993
Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine.
Cancer research. 53(9):2071-5 [PMID] 8481909.
View on: PubMed
1993
Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine.
The Biochemical journal. 291 ( Pt 1):131-7 [PMID] 8471032.
View on: PubMed
1993
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
The Journal of biological chemistry. 268(25):19118-25 [PMID] 8360194.
View on: PubMed
1993
Regulation of polyamine transport by polyamines and polyamine analogs.
Journal of cellular physiology. 155(2):399-407 [PMID] 8482732.
View on: PubMed
1993
Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators.
The Journal of biological chemistry. 268(35):26200-5 [PMID] 8253740.
View on: PubMed
1992
A comparison of the iron-clearing properties of 1,2-dimethyl-3-hydroxypyrid-4-one, 1,2-diethyl-3-hydroxypyrid-4-one, and deferoxamine.
Blood. 79(7):1882-90 [PMID] 1558978.
View on: PubMed
1992
Antitumor activity of N,N’-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
Cancer research. 52(9):2424-30 [PMID] 1568212.
View on: PubMed
1992
Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models.
Cancer chemotherapy and pharmacology. 30(3):179-82 [PMID] 1628365.
View on: PubMed
1992
Differential effects of the spermine analog, N1, N12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes.
Anticancer research. 12(4):1083-9 [PMID] 1503400.
View on: PubMed
1992
Regulatory and antiproliferative effects of N-alkylated polyamine analogues in human and hamster pancreatic adenocarcinoma cell lines.
Cancer chemotherapy and pharmacology. 30(3):183-8 [PMID] 1628366.
View on: PubMed
1992
Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.
Cancer research. 52(19):5359-63 [PMID] 1327507.
View on: PubMed
1992
Structural alterations in desferrioxamine compatible with iron clearance in animals.
Journal of medicinal chemistry. 35(25):4739-44 [PMID] 1469701.
View on: PubMed
1991
Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells.
Archives of biochemistry and biophysics. 284(2):238-44 [PMID] 1989509.
View on: PubMed
1991
Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.
Cancer research. 51(14):3715-20 [PMID] 2065327.
View on: PubMed
1991
Evaluation of desferrithiocin and its synthetic analogues as orally effective iron chelators.
Journal of medicinal chemistry. 34(7):2072-8 [PMID] 2066978.
View on: PubMed
1991
Increase in spermine content coordinated with siderophore production in Paracoccus denitrificans.
Journal of bacteriology. 173(7):2238-43 [PMID] 1826103.
View on: PubMed
1991
Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.
Molecular pharmacology. 39(4):487-94 [PMID] 2017149.
View on: PubMed
1991
Synthesis and biological evaluation of hydroxamate-based iron chelators.
Journal of medicinal chemistry. 34(11):3182-7 [PMID] 1956036.
View on: PubMed
1990
A comparative evaluation of iron clearance models.
Annals of the New York Academy of Sciences. 612:378-93 [PMID] 2127168.
View on: PubMed
1990
Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine.
The Biochemical journal. 268(1):207-12 [PMID] 2344358.
View on: PubMed
1990
Effect of N1,N14-bis(ethyl)homospermine on the growth of U-87 MG and SF-126 human brain tumor cells.
Cancer research. 50(11):3137-40 [PMID] 2334909.
View on: PubMed
1990
Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds.
The Biochemical journal. 267(2):331-8 [PMID] 2334396.
View on: PubMed
1990
Kinetics of iron acquisition from ferric siderophores by Paracoccus denitrificans.
Journal of bacteriology. 172(5):2650-7 [PMID] 2185228.
View on: PubMed
1989
Correlation between the effects of polyamine analogues on DNA conformation and cell growth.
Cancer research. 49(20):5591-7 [PMID] 2507131.
View on: PubMed
1989
Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues.
Cancer research. 49(14):3829-33 [PMID] 2544259.
View on: PubMed
1989
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
Cancer research. 49(3):639-43 [PMID] 2535963.
View on: PubMed
1989
Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells.
The Journal of biological chemistry. 264(20):11744-9 [PMID] 2745415.
View on: PubMed
1989
Major increases in spermidine/spermine-N1-acetyltransferase activity by spermine analogues and their relationship to polyamine depletion and growth inhibition in L1210 cells.
Cancer research. 49(22):6226-31 [PMID] 2804970.
View on: PubMed
1989
Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells.
Cancer research. 49(11):2959-64 [PMID] 2720656.
View on: PubMed
1989
Structure-function correlations of polyamine analog-induced increases in spermidine/spermine acetyltransferase activity.
Biochemical pharmacology. 38(9):1435-42 [PMID] 2497746.
View on: PubMed
1988
Control of ornithine decarboxylase activity in alpha-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues.
The Journal of biological chemistry. 263(22):11008-14 [PMID] 3134356.
View on: PubMed
1988
Demonstration of ferric L-parabactin-binding activity in the outer membrane of Paracoccus denitrificans.
Journal of bacteriology. 170(8):3711-7 [PMID] 3403511.
View on: PubMed
1988
Enzyme regulation as an approach to interference with polyamine biosynthesis–an alternative to enzyme inhibition.
Advances in enzyme regulation. 27:57-79 [PMID] 3250233.
View on: PubMed
1988
Modulation of polyamine biosynthesis and transport by oncogene transfection.
Biochemical and biophysical research communications. 157(1):264-70 [PMID] 3143363.
View on: PubMed
1988
Regulation of polyamine biosynthetic activity by spermidine and spermine analogs–a novel antiproliferative strategy.
Advances in experimental medicine and biology. 250:677-90 [PMID] 3076344.
View on: PubMed
1988
Selective regulation of S-adenosylmethionine decarboxylase activity by the spermine analogue 6-spermyne.
The Biochemical journal. 254(2):337-42 [PMID] 3178763.
View on: PubMed
1988
Synthetic polyamine analogues as antineoplastics.
Journal of medicinal chemistry. 31(6):1183-90 [PMID] 3373487.
View on: PubMed
1987
Microbial iron chelator-induced cell cycle synchronization in L1210 cells: potential in combination chemotherapy.
Cancer research. 47(22):6010-6 [PMID] 3664504.
View on: PubMed
1987
Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine.
The Biochemical journal. 242(2):433-40 [PMID] 3036091.
View on: PubMed
1987
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.
Cancer research. 47(11):2821-5 [PMID] 3567905.
View on: PubMed
1987
Structural determinants of spermidine-DNA interactions.
Biopolymers. 26(5):691-703 [PMID] 3593890.
View on: PubMed
1986
Comparison and characterization of growth inhibition in L1210 cells by alpha-difluoromethylornithine, an inhibitor of ornithine decarboxylase, and N1,N8-bis(ethyl)spermidine, an apparent regulator of the enzyme.
Cancer research. 46(12 Pt 1):6279-85 [PMID] 3096560.
View on: PubMed
1986
Effects of the Vibrio cholerae siderophore vibriobactin on the growth characteristics of L1210 cells.
Biochemical and biophysical research communications. 136(1):273-80 [PMID] 3707576.
View on: PubMed
1985
Biological properties of N4- and N1,N8-spermidine derivatives in cultured L1210 leukemia cells.
Cancer research. 45(5):2050-7 [PMID] 3921235.
View on: PubMed
1985
Characterization of L1210 cell growth inhibition by the bacterial iron chelators parabactin and compound II.
Cancer research. 45(10):4754-9 [PMID] 4027962.
View on: PubMed
1985
Influence of iron on in vivo proliferation and lethality of L1210 cells.
The Journal of nutrition. 115(3):369-74 [PMID] 3973748.
View on: PubMed
1985
Mechanism and stereospecificity of the parabactin-mediated iron-transport system in Paracoccus denitrificans.
The Journal of biological chemistry. 260(13):7936-44 [PMID] 4008483.
View on: PubMed
1984
Aliphatic chain length specificity of the polyamine transport system in ascites L1210 leukemia cells.
Cancer research. 44(1):126-8 [PMID] 6690029.
View on: PubMed
1984
Antineoplastic and antiherpetic activity of spermidine catecholamide iron chelators.
Biochemical and biophysical research communications. 121(3):848-54 [PMID] 6331431.
View on: PubMed
1984
Treatment with alpha-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells.
Journal of cellular physiology. 121(3):476-82 [PMID] 6438117.
View on: PubMed
1983
Spermidine requirement for cell proliferation in eukaryotic cells: structural specificity and quantitation.
Science (New York, N.Y.). 219(4588):1083-5 [PMID] 6823570.
View on: PubMed
1982
Biological properties of N4-spermidine derivatives and their potential in anticancer chemotherapy.
Cancer research. 42(10):4072-8 [PMID] 7105005.
View on: PubMed
1980
Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator.
Journal of medicinal chemistry. 23(10):1130-3 [PMID] 7420358.
View on: PubMed

Grants

Mar 2010 – May 2016
Iron Chelators Predicated on Desferrithiocin.
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Patents

Issued July 2018
Desferrithiocin Analogs and Uses Thereof
#10,010,535
Issued June 2018
Desferrithiocin Polyether Analogues (DIV of 15866)
#9,994,535
Published June 2018
Desferrithiocin Polyether Analogues (CON of 16590 (DIV of 15866)(11713)
#US 2019-0290990 A1
Published October 2017
Metabolically Programmed Metal Chelators and Uses Thereof
#US-2018-0140581
Issued August 2017
Desferrithiocin Polyether Analogues
#9,730,917
Published August 2017
Dosing Regimens for Treating Metal-Mediated Conditions
#US-2018-0036228-A1
Published June 2017
Use of HBED in Hemorrhagic Stroke and Closed Head Injury
#US-2018-0161295-A1
Issued February 2017
Desferrithiocin Polyether Analogues (DIV of 15181)
#9,567,309
Issued November 2015
Desferrithiocin Polyether Analogues (CON of UF#12096)
#9,174,948
Issued September 2015
Siderophore Conjugate Immunogenic Compositions and Vaccines (DIV of 13133)
#9,125,950
Issued August 2015
Desferrithiocin Polyether Analogues (CON of 11713)
#9,096,553
Issued September 2014
Siderophore Conjugate Immunogenic Compositions and Vaccines
#8,834,890
Published June 2014
Uses of 3'-Desferrithiocin Analogs
#US-2014-0323534-A1
Issued May 2014
Desferrithiocin Polyether Analogues
#8,722,899
Issued December 2013
Desferrithiocin Derivatives and Methods of Use Thereof
#8,604,216
Issued December 2012
Desferrithiocin Polyether Analogues
#8,324,397
Issued October 2012
Desferrithiocin Polyether Analogues
#8,278,458
Published March 2012
Desferrithiocin Polyether Analogues and Uses Thereof
#US-2012-0184586-A1
Published November 2011
Hydroxypolyomine Salts
#US-2013-0137772-A1
Issued August 2011
Thiazoline Acid Derivatives (CON)
#8,008,502
Issued February 2011
Iron Binding Agents (CON)
#7,879,886
Issued April 2010
Anti-Hypertensive Composition and Methods of Treatment (DIV)
#7,691,684
Published June 2009
Desferrithiocin Analogue Actinide Decorporation Agents
#US 2010-0137346 A1
Issued May 2009
Thiazoline Acid Derivatives (CON)
#7,531,563
Issued September 2008
Aminopolyamine Sample Pharmacophores
#7,423,182
Published December 2007
Chemical Resection of Pancreas (CON)
#2008-0108706-A1
Issued December 2006
Iron Binding Agents (CON)
#7,144,904
Issued October 2006
Thiazoline Acid Derivatives (CON)
#7,126,004
Published October 2006
Methods of Treating Hepatocellular Carcinoma With Denspm
#2007-0167528
Issued August 2006
Analogs of Biologially Active, Naturally Occuring Polyamines, Pharmaceutical Compositions and Methods of Treatment
#7,094,808
Issued June 2006
Thiazoline Acid Derivatives -(Reissue)
#RE39132
Published March 2006
Polyamine-Iron Chelator Conjugate (CON)
#2008/0096974 A2
Issued March 2005
Iron Binding Agents
#6,864,270
Published January 2005
Compositions and Methods for Inhibiting Pain
#2006-0160905-A1
Published January 2005
Antioxidant and Radical Scavenging Activity of Synthetic Analogs of Desferrithiocin (CON) (Abandoned in favor of 12/079,596 CON)
#20050234113
Issued January 2005
Anti-Hypertensive Composition and Methods of Treatment (CON)
#6,841,576
Issued November 2004
Method and Composition for Treatment of Irritable Bowel Disease
#6,818,656
Issued February 2004
Method and Composition of Treatment of Inflammatory Bowel Disease.
#6,689,788
Issued February 2004
Anti-Neoplastic, Anti-Viral or Anti-Retroviral Spermine Derivatives
#RE38,417 E
Issued December 2003
Method and Composition for Treatment of Irritable Bowel Disease (DIV)
#6,664,270
Issued November 2003
Method for Making HBED (owned by Genzyme)
#6,646,157
Published August 2003
Antioxidant and Radical Scavenging Activity of Synthetic Analogs of Desferrithiocin (CON)
#2004-0132789-A1
Issued May 2003
Thiazoline Acid Derivataives (CON)
#6,559,315
Issued March 2003
N,N'-BIS(2-Hydroxybenzyl) Ethylenediamine-N,N'-Diacetic Acid in Iron Chelating Therapy (CON)
#6,531,510
Issued February 2003
Thiazoline Acid Derivatives (CON)
#6,525,080
Issued February 2003
Thiazoline Acid Derivatives (CON)
#6,521,652
Issued December 2002
Hypusine Peptides (CON)
#6,492,489
Issued December 2002
Hypusine Peptides
#6,492,491
Published November 2002
Thiazoline Acid Derivatives
#US-2003-0236417-A1
Issued October 2002
Sterically Hindered Tetramines & Method for Their Production (CIP)
#6,472,426
Issued October 2002
Methods and Compositions (polyamines) for the Treatment of Diarrhea-predominant Irritable Bowel Syndrome.
#6,458,795
Issued September 2002
Polyamines and Anti-Diarrheal and Gastrointestinal Anti-Spasmodic Pharmaceutical Compositions and Methods of Treatment (DIV)
#6,455,591
Published August 2002
Antioxidant and Free Radical Scavenging Compositions
#US-2004-0044220-A1
Issued June 2002
Method and Composition for the Treatment of Diarrhea and Gastrointestinal Spasms.
#6,399,662
Issued March 2002
Anti-Neoplastic Anti-Viral or Anti-Removal Spermine Derivatives (CON)
#6,362,232
Published March 2002
Method and Composition for the Treatment of Diarrhea and Gastrointestinal Spasms (CON)
#US-2002-0193408-A1
Issued January 2002
Analogs of Biologically Active, Naturally Occurring Polyamines Pharmaceutical Compositions and Methods of Treatment (CON)
#6,342,534
Issued October 2001
Anti-Arrhythmic Composition and Methods of Treatment (CON)
#6,297,287
Issued August 2001
Method of Inhibiting Biosynthesis of EIf5A
#6,274,630
Issued July 2001
Sterically Hindered Tetramines & Method for Their Production
#6,262,125
Issued July 2001
Deoxyhypusine Reagent And Peptides Synthesis
#6,258,931
Issued June 2001
Hypusine Reagent For Peptide Synthesis
#6,248,866
Issued June 2001
N, N'-BIS(2-Hydroxybenzyl) Ethylenediamine-N, N'-Diacetic Acid In Iron Chelating Therapy (CIP) UF#1821
#6,242,492
Issued May 2001
Triamines based on Invention Disclosure titled A Metabolically Programmed Polyamine Analogue Antidiarrheals
#6,235,794
Issued February 2001
Analogs of Biologically Active Naturally Occurring Polyamines Pharmaceutical Composition and Methods of Treatment. (CIP)
#6,184,232
Published December 2000
N,N'-BIS(2-Hydroxy Benzyl) Ethylenediamine-N,N'-Diacetic Acid in Iron Chelating Therapy
#2001-0039295 A1
Issued December 2000
Chemical Resection of Pancreas
#6,160,022
Issued December 2000
Method and Composition for Treatment of Inflammatory Bowel Disease
#6,159,983
Issued November 2000
Anti-Neoplastic, Anti-Viral or Anti-Retroviral Spermine Derivatives
#6,147,262
Issued July 2000
Anti-Arrhythmic Composition And Methods of Treatment
#6,083,991
Issued July 2000
Thiazoline Acid Derivatives
#6,083,966
Issued March 2000
Anti-Neoplastic, Anti-Viral or Anti Retroviral Spermine Derivatives
#6,034,139
Issued October 1999
Hypusine Reagent for Peptide Synthesis
#5,973,113
Issued October 1999
Hydroxy Polyamines
#5,962,533
Issued March 1999
Methods and Compositions for the Treatment of Cerebro-Neurodegeneration
#5,886,051
Issued March 1999
Sterically Hindered Tetramines & Method for their Production
#5,886,050
Issued February 1999
Anti-Neoplastic, Anti-Viral or Anti-Retroviral Spermine Derivatives.
#5,866,613
Issued December 1998
Methods and Bicyclic Polyamine Compositions for the Tretament of Inflammation
#5,843,959
Issued November 1998
Thiazoline Acid Derivatives
#5,840,739
Issued October 1998
Anti-Neoplastic, Anti-Viral or Anti-retroviral Spermine Derivatives
#5,827,894
Issued April 1998
Method for Synthesis of Rhizoferrin
#5,739,395
Issued October 1997
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Mosquito Insecticidal Composition
#5,681,837
Issued October 1997
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Administering Spermine Derivative; Mosquito Growth Controller (DIV)
#5,679,682
Issued October 1997
Sterically Hindered Tetraamines and Method for Their Production Administering Anti-diarrhea, Anti-peristaltic or Gastrointestinal Anti-spasmodic Agent08/
#5,677,351
Issued October 1997
Polyamines and Anti-diarrheal and Gastrointestinal Anti-spasmodic Pharmaceutical Compositions and Methods of Treatment
#5,677,352
Issued August 1997
Sterically Hindered Tetraamines and Method for Their Production Insecticides, Pharmaceuticals
#5,656,671
Issued October 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Vibriobactin or Parabactin to Inhibit Proliferation of Malignant Cells by Complexing Iron to Interfere with Their Mechanism for Iron Acquisition
#5,569,666
Issued August 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Iron Chelating Agent to Treat Psoriasis
#5,550,144
Issued August 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering to Human or Animal Effective Amount to Parabactin or Salts to Inhibit Proliferation of Malignant Cells; Antileukemia Agent
#5,545,650
Issued August 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering to Human or Animal Effective Amount to Parabactin or Salts to Inhibit Proliferation of Malignant Cells
#5,545,649
Issued July 1996
Anti-neoplastic Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,541,207
Issued July 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,536,739
Issued July 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,536,738
Issued May 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Anticarcinogenic Agents from Polyamide Derivatives
#5,519,041
Issued May 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Psoriasis
#5,514,695
Issued April 1996
Anti-hypertensive Composition and Methods of Treatment Administering Polyalkylene-amines or Salts Thereof
#5,510,390
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment an Iron Chelator, Malaria
#5,498,622
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Method of Treatment Treatment Of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives With Catechol
#5,496,841
Issued March 1996
Anti-neoplastic Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,837
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,839
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,840
Issued March 1996
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Treatment of Skin Disorders Such as Psoriasis with Spermidine Amide Derivatives with Catechol
#5,496,838
Issued February 1996
Method for Preparing Desferrioxamine B and Homologs Thereof N-benzyloxy-1,5-diaminopentane Selectively Protected at Primary Amine Site Reacted with Anhydride to Produce Carboxylic Acid, Acylation, Reacting with Diamine, Hydrogenolysis, Deprotecting
#5,493,053
Issued November 1995
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,466,702
Issued October 1995
Polyamines and Anti-diarrheal and Gastrointestinal Anti-spasmodic Pharmaceutical Compositions and Methods of Treatment
#5,462,970
Issued October 1995
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives
#5,455,277
Issued February 1995
Polyamines and Anti-diarrheal and Gastrointestinal Anti-spasmodic Pharmaceutical Compositions and Methods of Treatment (CIP)
#5,393,757
Issued February 1995
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Specific Iron Chelator
#5,391,563
Issued November 1994
Method for Synthesis of Desferrioxamine B, Analogs and Homologs Thereof Iron Chelate Compounds with Polyether Derivatives
#5,367,113
Issued November 1994
Analogs of Desferrioxamine B and Method for Synthesis Thereof Treatment Of Thalassemia (DIV)
#5,364,965
Issued August 1994
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Bis-hexahydropyrimidinylakyl Compounds (DIV)
#5,342,945
Issued June 1994
Analogs of Desferrioxamine B and Method for Synthesis Thereof Deblocking, Condensation, Alkylation, Acrylation, Reduction
#5,322,961
Issued March 1994
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment
#5,292,775
Issued October 1993
Method for Synthesis of Desferrioxamine B, Analogs and Homologs Thereof
#5,254,724
Issued December 1992
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Antimalarial Agents
#5,173,505
Issued July 1992
Anti-neoplastic, Anti-viral and Ribonucleotide Reductase Activity Affecting Pharmaceutical Compositions and Methods of Treatment Administering Parabactin or Derivative
#5,128,353
Issued February 1992
Anti-neoplastic, Anti-viral or Anti-retroviral Spermine Derivatives Antipsoriasis, Insecticides (CIP)
#5,091,576
Issued January 1991
Method for the Synthesis of Desferrioxamine B and Analogs Thereof Multicondensations and Reductions, Starting with a Cyanoalkanal And an Hydroxylamine Derivative
#4,987,253
Issued January 1986
Synthesis of Parabactin and Homologs Thereof Iron Overload Syndromes
#4,565,874
Issued March 1985
Methods and Intermediates for the Preparation of Spermidine, Homospermidine and Norspermidine Hydrogenation of Azadinitriles
#4,505,861

Teaching Profile

Courses Taught
2009-2013
PHA7979 Advanced Research
2011-2013
PHA6910 Supervised Research
2009-2013
PHA6934 Seminar in Medicinal Chemistry
2009-2013
PHA7980 Research for Doctoral Dissertation
2010-2012
PHA6971 Masters Research
2010,2012
PHA6447 Drug Design
2009,2011
PHA5906 Research in Med Chem

Contact Details

Phones:
Business:
(352) 273-7725
Emails:
Business:
rayb@ufl.edu