A chemical compound made from a type of bacteria discovered in the Florida Keys by a University of Florida pharmacy researcher has shown effectiveness in fighting colon cancer in preclinical experiments. Writing online in the Journal of Pharmacology and Experimental Therapeutics, scientists say the compound — known as largazole because it was first found near Key Largo — inhibits human cancer cell growth in cultures and rodent models by attacking a class of enzymes involved in the packaging and structure of DNA. More study is needed, but scientists hope that the discovery will lead to new treatments for the roughly 50,000 people struck with colorectal cancer each year in the United States. Researchers are enthusiastic because in addition to having the marine bacteria as a natural source of the chemical, they have been able to synthetically produce the active chemical compound extracted from the bacteria.
A University of Florida genetics researcher has received $10.6 million to further a national effort to use genetic data to more effectively pinpoint which medications and treatments are best for individual patients. Julie A. Johnson, Pharm.D., the V. Ravi Chandran Professor in Pharmaceutical Sciences and chair of pharmacotherapy and translational research in the College of Pharmacy, is one of 14 researchers who have received a five-year award as part of the National Institute of Health’s Pharmacogenomics Research Network.
In a race against time, University of Florida marine researchers are hurrying to collect underwater marine algae samples in the Florida Keys while an ever-growing Gulf oil spill steadily migrates toward Florida, already reaching the Emerald Coast in the Panhandle.
Hendrik Luesch collaborating with researchers at Harvard and Scripps, published his findings. Researchers from the University of Florida have discovered a molecule that may help enhance our body’s natural antioxidant self-healing powers without the help of vitamins. This discovery could potentially help people stay healthy and disease free. …
Alcohol-related problems cost society in economic terms approximately $185 billion a year, according to the National Institute on Alcohol Abuse and Alcoholism. The catastrophic costs in human terms cannot be determined. Addiction to alcohol results in human tragedy not only to the individual but also for families who love and support those caught in this grim illness. Joanna Peris, Ph.D., an associate professor in the department of pharmacodynamics in the College of Pharmacy, is conducting basic research that looks at the changes in neurochemistry in the brains of rats choosing to drink alcohol. This research may discover what chemicals cause the cravings for alcohol and lead to a breakthrough in how to control the urge to drink too much. “My research will help us understand what goes on in the brain during excessive drinking,” Peris said. “This may lead us to come up with a therapy.”
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They couldn’t write notes. It was a problem Ann Snyder, Pharm.D., noticed in almost all her students. The notes Snyder is talking about aren’t the kind students take in a lecture hall. Rather, many…
W. Thomas “Tommy” Smith, Pharm.D., J.D., a clinical assistant professor of pharmaceutical outcomes and policy has received a one-year award totaling more than $56,600 from Cephalon, Inc. The award supports research conducted by Smith and co-investigator, Professor David Brushwood, R.Ph., J.D., titled Pharmacist Responsibility for Screening of Opioid…
The global burden of prostate cancer in men of African descent is the focus of a landmark collaborative conference organized by Folakemi Odedina, Ph.D., a professor in pharmaceutical outcomes and policy, and University of Florida Health Science Center researchers. Leaders from the College of Medicine, the College of Pharmacy, Prostate Net and the 100 Black Men of Jacksonville,Inc. joined together in August to host the first “The Science of Global Prostate Cancer Disparities in Black Men” conference in Jacksonville, Fla.
This fall, the University of Florida College of Pharmacy has enlisted a few good men and women into graduate studies in drug evaluation, policy and safety sciences through a new scholarship opportunity.