Search results for natural product

Showing 71 - 80 of 95 results

Chemical Synthesis and Drug (or Probe) Development

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/chemical-synthesis-and-drug-or-probe-development/

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

Chemical Synthesis and Drug (or Probe) Development

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/chemical-synthesis-and-drug-or-probe-development/

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

Microbial Genomics and Biosynthetic Engineering

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/microbial-genomics-and-biosynthetic-engineering/

Genomic screening of marine cyanobacteria for the detection of targeted secondary metabolite biosynthetic genes has been achieved through fosmid DNA libraries construction using HMW metagenomic DNA isolated from environmental cyanobacterial samples. Conserved enzymatic steps shared by diverse biosynthetic gene clusters are used as starting point for the design of degenerate primers from the corresponding biosynthetic...

Functional Genomics and High-Throughput Screening

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/functional-genomics-and-high-throughput-screening/

In parallel efforts, we are carrying out studies to reveal the function and action of genes/proteins that are putatively involved in cancer, aging and neurodegeneration. Candidate genes identified by high-throughput genome-wide cDNA and RNAi screening are subjected to molecular and biological characterization including structure-function studies in cell- and animal-based models. The ultimate goal is to...

Target Identification and Mode of Action Studies

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/target-identification-and-mode-of-action-studies/

Drug target identification and mode of action studies for molecules discovered through phenotypic screens usually represent a bottleneck in drug discovery. The limited abundance of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes chemical synthesis in a timely manner. Genomic and proteomic...

Discovery of Bioactive Marine Natural Products

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/discovery-of-bioactive-marine-natural-products/

Approximately half of all current drugs are derived from natural products, demonstrating their potential for drug discovery. The structural diversity and biological activity displayed by natural products may be attributed to a long evolutionary selection process. In our quest for small molecules with biomedical utility for various disease indications we mainly investigate natural products. In...

2019 UF Drug Discovery Symposium brings together experts from across Florida

The third UF Drug Discovery Symposium brought a record-breaking 180 participants, including many of Florida’s major players in the drug discovery field, to Hotel Indigo in Gainesville on April 25–26. The symposium — hosted by the University of Florida College of Pharmacy’s Center for Natural Products, Drug Discovery and Development, or CNPD3 — featured a keynote...

Center for Natural Products, Drug Discovery and Development (CNPD3)

http://cnpd3.pharmacy.ufl.edu/

  Mission The mission of the Center for Natural Products, Drug Discovery and Development, or CNPD3, is to foster early-stage drug discovery by providing the infrastructure, chemical libraries and expertise to screen for disease-relevant targets and for drug-like disease-modifying molecules that modulate target activity. The CNPD3 provides the academic home for the identification of drug leads...