Search results for natural product

: Hendrik Luesch) Guangde Jiang, New Frontiers Scholar Award of New Frontiers in Natural Products Discovery Corteva Agriscience, 2019 (Mentor: Yousong Ding) David Brumley, Selected

Killers, (Mentor: Robert Huigens III) Chip Norwood, Complexity-to-Diversity on the Indole-Containing Natural Product Vincamine, (Mentor: Robert Huigens III) Ran Zuo, Developing

Elsadek, Genomic and targeted approaches unveil targets of an antifungal natural product, (Mentor: Hendrik Luesch) 2019 – Winners from Medicinal Chemistry Oral Competition

natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression. Free Radic Biol Med. 2020;146:306-323. (Epub 2019

large-scale or focused synthetic libraries as well as natural products for small molecule modulators of target or pathway activity. Furthermore, dietary components including marine

few rounds of dilution/PCR screening. Using this approach we isolated hybrid NRPS/PKS gene clusters encoding for various natural products from phylogenetically diverse

is the pharmacophore of the natural product and liberated during protein-assisted thioester hydrolysis to largazole thiol.  We determined that largazole inhibits HDACs in vivo

of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes

And Chair, Debbie And Sylvia DeSantis Chair In Natural Products Drug Discovery And Development

Chemistry Department the following fall to conduct research on drug discovery of specialized metabolites from marine natural products. Her efforts will then include synthesis