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A UF College of Pharmacy researcher team led by Dr. Hendrik Luesch recently developed a novel molecule based on marine cyanobacteria, Apra S10, to target pancreatic cancer cells.
With the funding from the Maximizing Investigators’ Research Award, Ding aims to access and expand chemical diversity of microbes through the use of new, innovative strategies.
Dr. Yousong Ding, an associate professor of medicinal chemistry, contributed to the study that was published in the journal Communications Biology.
A 14,500-square-foot integrated drug discovery lab will house some of UF’s medicinal chemistry faculty.
A promising medicinal compound discovered in a marine organism by University of Florida pharmacy researchers is showing its versatility against multiple diseases. Having already demonstrated its power as an anti-tumor agent, largazole, produced by a cyanobacterium inhabiting coral reefs, has shown a new potential benefit for treating serious fractures, osteoporosis and other bone diseases, according...
Genomic screening of marine cyanobacteria for the detection of targeted secondary metabolite biosynthetic genes has been achieved through fosmid DNA libraries construction using HMW metagenomic DNA isolated from environmental cyanobacterial samples. Conserved enzymatic steps shared by diverse biosynthetic gene clusters are used as starting point for the design of degenerate primers from the corresponding biosynthetic...
Director: Hendrik Luesch, Ph.D., Debbie and Sylvia DeSantis Chair in Natural Products Drug Discovery and Development Department of Medicinal Chemistry Jane Aldrich, Ph.D. Qi-Yin Chen, Ph.D. Yousong Ding, Ph.D. Robert Huigens III, Ph.D. Margaret O. James, Ph.D. Chenglong Li, Ph.D. Christopher R. McCurdy, Ph.D. Ranjala Ratnayake, Ph.D. Chengguo (Chris) Xing, Ph.D. Department of Chemistry Steven Bruner,...
The department of medicinal chemistry is located in the University of Florida College of Pharmacy and is an integral part of UF Health. The department has excellent research facilities dedicated to major areas of medicinal chemistry research, and faculty in the department have been highly successful in attracting extramural research support. UF’s Preeminence initiative in...
Research in the Luesch lab lies at the interface of chemistry and biology and addresses multiple aspects of the drug discovery process ranging from assay development, identification and structure determination of bioactive small molecules with a focus on marine natural products, studies toward their mechanism of action, chemical synthesis and drug development of promising agents, the engineering of their...
