Dr. Hendrik Luesch and a team of researchers have discovered a novel marine natural product that binds to a new site of tubulin, an important target for cancer drugs.
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The 10 medicinal chemistry faculty currently serve as principal investigators on 18 different federally funded grants worth more than $18.4 million.
Alumni and graduate students who worked under Luesch’s mentorship came from across the world to present at the Gordon Research Conference on Marine Natural Products.
Researchers in the UF College of Pharmacy teamed with collaborators in Singapore to study a novel drug candidate with marine origins as a new method to prevent or treat vision loss.
Luesch presented on the expanding chemical space for drug discovery at the conference in Kuwait City.
A UF College of Pharmacy researcher team led by Dr. Hendrik Luesch recently developed a novel molecule based on marine cyanobacteria, Apra S10, to target pancreatic cancer cells.
With the funding from the Maximizing Investigators’ Research Award, Ding aims to access and expand chemical diversity of microbes through the use of new, innovative strategies.
Known as the Maximizing Investigators’ Research Award, the grant will fund several of Huigens’ research projects, including efforts to develop compounds that will eliminate bacterial biofilm-associated infections.
Led by principal investigator, Rob Huigens, Ph.D., an assistant professor of medicinal chemistry, the grant aims to establish a drug discovery pipeline to generate and identify new small molecules that possess anticancer activities.
The researchers found a more efficient way to harvest the UV-absorbing amino acid known as shinorine, which marine organisms like cyanobacteria and macroalgae produce.