Search results for natural product

The College of Pharmacy’s Center for Natural Products, Drug Discovery and Development, or CNPD3, hosted the 2019 UF Drug Discovery Symposium, April 25-26, 2019, at the Hotel

in Gainesville on April 25–26. The symposium — hosted by the University of Florida College of Pharmacy’s Center for Natural Products, Drug Discovery and Development, or CNPD3 — featured

Approximately half of all current drugs are derived from natural products, demonstrating their potential for drug discovery. The structural diversity and biological activity

of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes

as natural products for small molecule modulators of target or pathway activity. Sample Publications: Liu, Y.; Kern, J. T.; Walker, J. R.; Johnson, J. A.; Schultz, P. G.; Luesch, H

few rounds of dilution/PCR screening. Using this approach we isolated hybrid NRPS/PKS gene clusters encoding for various natural products from phylogenetically diverse

to the preparation of a series of analogues.  SAR studies revealed that the thiol group is the pharmacophore of the natural product and liberated during protein-assisted thioester

to the preparation of a series of analogues.  SAR studies revealed that the thiol group is the pharmacophore of the natural product and liberated during protein-assisted thioester

., an associate professor of medicinal chemistry in the UF College of Pharmacy, a part of UF Health. Luesch’s marine natural products laboratory offers the first investigation