Search results for natural product

Showing 41 - 50 of 228 results

UF Drug Discovery Symposium April 2019

https://cnpd3.pharmacy.ufl.edu/news-2/uf-drug-discovery-symposium/uf-drug-discovery-symposium-april-2019-2/

The College of Pharmacy’s Center for Natural Products, Drug Discovery and Development, or CNPD3, hosted the 2019 UF Drug Discovery Symposium, April 25-26, 2019, at the Hotel

Discovery of Bioactive Marine Natural Products

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/discovery-of-bioactive-marine-natural-products/

Approximately half of all current drugs are derived from natural products, demonstrating their potential for drug discovery. The structural diversity and biological activity

Target Identification and Mode of Action Studies

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/target-identification-and-mode-of-action-studies/

of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes

Functional Genomics and High-Throughput Screening

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/functional-genomics-and-high-throughput-screening/

as natural products for small molecule modulators of target or pathway activity. Sample Publications: Liu, Y.; Kern, J. T.; Walker, J. R.; Johnson, J. A.; Schultz, P. G.; Luesch, H

Microbial Genomics and Biosynthetic Engineering

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/microbial-genomics-and-biosynthetic-engineering/

few rounds of dilution/PCR screening. Using this approach we isolated hybrid NRPS/PKS gene clusters encoding for various natural products from phylogenetically diverse

Chemical Synthesis and Drug (or Probe) Development

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/chemical-synthesis-and-drug-or-probe-development/

to the preparation of a series of analogues.  SAR studies revealed that the thiol group is the pharmacophore of the natural product and liberated during protein-assisted thioester

Chemical Synthesis and Drug (or Probe) Development

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/chemical-synthesis-and-drug-or-probe-development/

to the preparation of a series of analogues.  SAR studies revealed that the thiol group is the pharmacophore of the natural product and liberated during protein-assisted thioester