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to the preparation of a series of analogues. SAR studies revealed that the thiol group is the pharmacophore of the natural product and liberated during protein-assisted thioester
is the pharmacophore of the natural product and liberated during protein-assisted thioester hydrolysis to largazole thiol. We determined that largazole inhibits HDACs in vivo
Chair of Medicinal Chemistry and the Nicholas Bodor Professor in Drug Discovery
Chenglong Li, Ph.D., obtained his B.Sc. in chemistry and M.Sc. in physical chemistry from Beijing University in 1985 and 1988, re…
synthesis through the invention of novel chemical methodologies and strategies and to discover natural product-based chemotherapeutics.
March 24th, 2021, 8AM-9AM, via Zoom Dr. Kim’s presentation is titled “Awakening and Refactoring of Natural Product Biosynthetic Gene Cluster in Streptomyces“
Wednesday, March 12, from 10 – 11 a.m. in C1-004 Dr. Lowell’s presentation title is “Antibiotic development through natural product modification.”
August 31st, 2022, 10AM-11AM in Communicore C1-04. Dr. Caro-Diaz presentation is titled “Bioactive Marine Algae Natural and Pseudo-Natural Products”
Wednesday, Oct. 25, from 10 – 11 a.m. in Communicore C1-017 Dr. Kou-San Ju’s presentation is titled “Genomics-Accelerated Discovery and Biosynthesis of Phosphonate Natural Products.”
Wednesday, January 24th 2024 from 10:00 AM – 11:00 AM in Communicore C1-015 Dr. Linington’s presentation title is “Informatics-Based Approaches to Natural Products Discovery in an Age of Reisolation”
Thursday, November 17, 10:00am – 11:00am in Communicore C1-017 Dr. Tang’s presentation is titled “Chemistry and Biology of Fungal Natural Products”
