Search results for natural product

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

1923 The first entering class of 43 students registered for classes in Science Hall, now Flint Hall and Peabody Hall. Townes R. Leigh, Head of the Department of Chemistry, was appointed Director of the School of Pharmacy by President Murphree. The School of Pharmacy offered the Graduate of Pharmacy degree (Ph.G.), the Pharmaceutical Chemist degree...

A novel strategy developed by UF Health researchers has yielded several promising compounds to fight inflammation and diseases such as colorectal cancer.

The 37th Annual Research Showcase featured more than 110 poster presentations, 12 oral presentations and a keynote address from Dr. Angela Kashuba.

A chemical compound made from a type of bacteria discovered in the Florida Keys by a University of Florida pharmacy researcher has shown effectiveness in fighting colon cancer in preclinical experiments. Writing online in the Journal of Pharmacology and Experimental Therapeutics, scientists say the compound — known as largazole because it was first found near...

Dean Johnson shares her reflection on the college's heroic response to the COVID-19 pandemic.

Hendrik Luesch, Ph.D., and Yousong Ding, Ph.D., co-authored the study that identified the genes responsible for producing dolastatin 10.

The college has five academic departments that have a unique research focus, are highly successful in attracting extramural research support, and are an integral part of the University of Florida Health Science Center. Faculty in the departments lead the training and education of students in the UF College of Pharmacy and maintain robust research activities that position the...

Approximately half of all current drugs are derived from natural products, demonstrating their potential for drug discovery. The structural diversity and biological activity displayed by natural products may be attributed to a long evolutionary selection process. In our quest for small molecules with biomedical utility for various disease indications we mainly investigate natural products. In...