Search results for natural product

Showing 21 - 30 of 92 results

Chemical Synthesis and Drug (or Probe) Development

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/chemical-synthesis-and-drug-or-probe-development/

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

Chemical Synthesis and Drug (or Probe) Development

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/chemical-synthesis-and-drug-or-probe-development/

For selected compounds (by ourselves or in collaboration), we are devising synthetic methods to probe structure–activity relationships (SAR) and to obtain larger quantities of material for biological evaluation, including toxicity, pharmacokinetic and efficacy studies in animal models, which we will carry out in due course. Molecules of interest include largazoles and apratoxins, which we discovered and...

College History

1923 The first entering class of 43 students registered for classes in Science Hall, now Flint Hall and Peabody Hall. Townes R. Leigh, Head of the Department of Chemistry, was appointed Director of the School of Pharmacy by President Murphree. The School of Pharmacy offered the Graduate of Pharmacy degree (Ph.G.), the Pharmaceutical Chemist degree...

Compound discovered in Florida Keys shows early promise as colon cancer treatment

A chemical compound made from a type of bacteria discovered in the Florida Keys by a University of Florida pharmacy researcher has shown effectiveness in fighting colon cancer in preclinical experiments. Writing online in the Journal of Pharmacology and Experimental Therapeutics, scientists say the compound — known as largazole because it was first found near...

COVID-19: One Year Later

Dean Johnson shares her reflection on the college's heroic response to the COVID-19 pandemic.

Departments

The college has five academic departments that have a unique research focus, are highly successful in attracting extramural research support, and are an integral part of the University of Florida Academic Health Center. A sixth department, pharmacy education and practice, is dedicated to enhancing clinical education and practice. Faculty in the departments lead the training and education of...

Discovery of Bioactive Marine Natural Products

https://mc.pharmacy.ufl.edu/research/faculty-research-areas/marine-natural-products-drug-discovery-and-development/discovery-of-bioactive-marine-natural-products/

Approximately half of all current drugs are derived from natural products, demonstrating their potential for drug discovery. The structural diversity and biological activity displayed by natural products may be attributed to a long evolutionary selection process. In our quest for small molecules with biomedical utility for various disease indications we mainly investigate natural products. In...