Target Identification and Mode of Action Studies
of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes
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of compound available for characterization studies is an additional fundamental concern in natural products drug discovery, particularly if the structural complexity precludes
. Researchers tested the natural products in multiple cell-based and animal models and found activation of a signaling pathway responsible for fighting off inflammation
expression” Nature Cell Biol. 2010, 12, 758–767. Luesch, H.; Abreu, P. “A natural products approach to drug discovery: probing modes of action of antitumor agents by genome-scale
Dr. Hendrik Luesch and a team of researchers have discovered a novel marine natural product that binds to a new site of tubulin, an important target for cancer drugs.
Burris was honored for his development of an exercise mimetic derived from a natural product source.
, Ph.D., a professor and chair of medicinal chemistry and the Debbie and Sylvia DeSantis Chair in Natural Products Drug Discovery and Development. “In an era when competition
Hendrik Luesch, Ph.D., the Debbie and Sylvia DeSantis Chair in Natural Products Drug Discovery and Development in the UF College of Pharmacy, was one of two faculty named
Alumni and graduate students who worked under Luesch’s mentorship came from across the world to present at the Gordon Research Conference on Marine Natural Products.
DeSantis Chair in Natural Products Drug Discovery and Development. Keynote speaker, Frank Koehn, Ph.D., a research fellow – Natural Products/World Wide Medicinal Chemistry, Pfizer, Inc
Hendrik Luesch’s discovery and complete chemical and pharmacological characterization of a novel marine natural product that can potentially fight cancer has earned him a 2021 UF Innovation of the Year award.