Search results for natural product

Approximately half of all current drugs are derived from natural products, demonstrating their potential for drug discovery. The structural diversity and biological activity displayed by natural products may be attributed to a long evolutionary selection process. In our quest for small molecules with biomedical utility for various disease indications we mainly investigate natural products. In...

Research in the Luesch lab lies at the interface of chemistry and biology and addresses multiple aspects of the drug discovery process ranging from assay development, identification and structure determination of bioactive small molecules with a focus on marine natural products, studies toward their mechanism of action, chemical synthesis and drug development of promising agents, the engineering of their...

University of Florida pharmacy researchers have modified a toxic chemical produced by tiny marine microbes and successfully deployed it against laboratory models of colon cancer. Writing today in ACS Medicinal Chemistry Letters, UF medicinal chemists describe how they took a generally lethal byproduct of marine cyanobacteria and made it more specifically toxic — to cancer...

The UF Center for Natural Products, Drug Discovery and Development hosted the 6th UF Drug Discovery Symposium April 15-16 in Gainesville.

Hendrik Luesch’s discovery and complete chemical and pharmacological characterization of a novel marine natural product that can potentially fight cancer has earned him a 2021 UF Innovation of the Year award.

The virtual event will be held April 22-23 and hosted by the Center for Natural Products, Drug Discovery & Development.

The study examined the marine natural product largazole as a treatment option for brain diseases is featured on the July 2020 ACS Chemical Neuroscience journal cover.