Research in the Luesch lab lies at the interface of chemistry and biology and addresses multiple aspects of the drug discovery process ranging from assay development, identification and structure determination of bioactive small molecules with a focus on marine natural products, studies toward their mechanism of action, chemical synthesis and drug development of promising agents, the engineering of their biosynthetic pathways and development of heterologous expression systems, to the discovery of novel drug targets. Other products of our research are unique small molecule tools for chemical biology to probe gene and protein functions.
Specific areas of research
- Discovery of Bioactive Marine Natural Products
- Target Identification and Mode of Action Studies
- Chemical Synthesis and Drug (or Probe) Development
- Microbial Genomics and Biosynthetic Engineering
- Functional Genomics and High-Throughput Screening
Treasure Hunt: Cyanobacteria
The Luesch lab gratefully acknowledges past and current funding from the following sources:
- Debbie and Sylvia DeSantis Endowed Chair/Professorship
- American Heart Association
- Florida Sea Grant College Program
- UF Health Cancer Center
- The Evelyn F. & William L. McKnight Brain Institute of the University of Florida
- James & Esther King Biomedical Research Program
- Florida Institute of Oceanography
- National Institutes of Health (NCI, NIGMS)
- Bankhead-Coley Cancer Research Program
- University of Florida Research Opportunity Fund
- Ocala Royal Dames for Cancer Research, Inc.
Diving With a Donor
Learn more about UF College of Pharmacy alumna and supporter Debbie DeSantis, ʼ82, and her interest in natural products. This video highlights a May 2015 trip to the Florida Keys to collect cyanobacteria.
This lab is managed by Hendrik Luesch