- Ph.D. Endocrinology, University of California, San Francisco, 1982
- A.B. Biochemistry, Vassar College, Poughkeepsie, NY, 1977
Dr. Keller-Wood’s overall research interest is the physiologic adaptations to pregnancy and effects of maternal physiology on fetal maturation and growth. Her areas of current interest are:
- The laboratory has a long standing interest in the effects of the adrenal hormone cortisol. Secretion of cortisol is increased in pregnancy, and this hormone mediates important adaptive physiologic effects necessary for regulating blood glucose, blood pressure, fluid and electrolyte excretion, appetite, and mood. The research team is interested in the role of the normal increase in cortisol and its action in both the mother and in the fetus, as well as the adverse effects that occur when there are excess increases in maternal cortisol in pregnancy, as occurs with maternal stress.
- A major current focus of the laboratory is the adverse effects of maternal cortisol on fetal and neonatal cardiac health and metabolism. Excess maternal cortisol secretion in late gestation is associated with an increased risk of fetal death. Researchers are using a combination of techniques to determine the effects of cortisol on fetal cardiac maturation and on function during labor and delivery. These include in vivo techniques such as telemetry to continuously monitor fetal ECG and arterial pressure during labor and delivery, transcriptomic methods to determine altered expression of genes as a result of pre-term cortisol exposure, biochemical techniques to assess mitochondrial function, and metabolomic techniques to assess shifts in metabolism.
- Keller-Wood’s research team is interested in potential effects of maternal exposure to endocrine disrupting chemicals in the environment on fetal development. In addition, they are interested in effects of triclosan on metabolism and neuroendocrine maturation and function in the fetus and the newborn.
- Her research team recently began studies to examine the effects of maternal stress on the maternal microbiome, and effects of altered maternal bacterial populations on fetal and neonatal health.
- She is a collaborator on a grant to investigate the cardiorenal adaptions to pregnancy in women who become pregnant through assisted reproductive technologies (ART). ART has been associated with increases in maternal cardiorenal disease and in the incidence of small for gestation infants. She is the PI of the analytic core for this P01 which performs analysis of plasma, serum and urine to determine endocrine, electrolyte and other endpoints.
Charles E. Wood, Ph.D.; Department of Physiology and Functional Genomics, University of Florida
Belen Rabaglino, DVM, Ph.D; Centro de Excelencia en Procesos y Productos de Córdoba, Argentina
Eric Triplett, Ph.D; Department of Microbiology; University of Florida
Kirk Conrad, M.D.; Department of Physiology and Functional Genomics, University of Florida
Arthur Edison, Ph.D.; Department of Biochemistry and Molecular Biology, University of Georgia
Peter Stacpoole, Ph.D.; M.D.; Department of Medicine, Division of Endocrinology, University of Florida
Matthew Merritt, Ph.D.; Department of Biochemistry and Molecular Biology, University of Florida
Stephanie Wohlgemuth, Ph.D.; Department of Animal Sciences, University of Florida
Jennifer Co-Vu, M.D.; Department of Pediatrics, Congenital Heart Center, University of Florida
Current Ph.D. Students
Serene Joseph, BS
Mengchen Li, BS, MS
Recent and Current Funding
- NIH R01 HD087306 Effects of maternal cortisol on perinatal cardiac metabolism and function
- NIH R21 HD091599 Therapeutic use of dichloroacetate in treatment of perinatal mitochondrial deficiency and cardiac dysfunction
- NIH R21 AI 120195 Modeling the fetal microbiome (Wood and Triplett, PIs)
- NIH P01 HD065647 Corpus luteal contribution to maternal pregnancy physiology and outcomes in ART (Conrad, PI; Keller-Wood , PI of Analytic Core; Co-I Project I)