- Pharm.D., University of Tennessee College of Pharmacy
- B.S. in Biology, with a concentration in microbiology, Memphis State University
Dr. Markowitz has been credentialed by the Board of Pharmaceutical Specialties in Psychiatric Pharmacy since 1997. Following his training, Dr. Markowitz served for a number of years as a hospital-based Clinical Specialist in Psychiatry within the Institute of Psychiatry at the Medical University of South Carolina (MUSC) in Charleston, South Carolina. He eventually entered into a primary faculty research position in the MUSC College of Pharmacy’s Department of Pharmaceutical & Biomedical Sciences with a dual appointment in the Department of Psychiatry and Behavioral Sciences where he had remained prior to joining UF in 2009.
- American Society of Hospital Pharmacists
- American Society of Clinical Pharmacology and Therapeutics
- American College of Clinical Pharmacy
- College of Psychiatric and Neurologic Pharmacists
- Dr. Markowitz’s research program has encompassed both in vitro and in vivo investigations including normal volunteer pharmacokinetic studies directed at the assessment of drug-drug interactions in psychopharmacology, botanical-drug interactions, as well as their associated clinical effects. More recently, the research program has focused on variability in drug metabolism, disposition, and therapeutic response as a consequence of genetic variability which influences both drug transporters and hepatic enzymes. He has received research support from both the pharmaceutical industry and the National Institutes of Health.
Zhu H-J, Langaee TY, Gong Y, Wang X, Pepine CJ, Cooper-DeHoff RM, Johnson JA, Markowitz JS. CES1P1 variant −816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril. Eur J Clin Pharmacol 2016;72:681-687.
Wang X, Zhu H-J, Munoz J, Gurley BJ, Markowitz JS. An ex vivo approach to botanical-drug interactions: A proof of concept study. J Ethnopharmacol 2015;163:149-156. (PMID: 25623616)
Kawaguchi-Suzuki M, Frye RF, Zhu H-J, Brinda BJ, Chavin KD, Bernstein HJ, Markowitz JS. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug Metab Dispos 2014;42:1611-1616 (PMID: 25028567)
Zhu HJ, Wang X, Gawronski B, Brinda B, Angiolillo D, Markowitz JS. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. J Pharmacol Exp Ther 2013;344:665-672. (PMID: 23275066)
Zhu H-J, Brinda B, Froehlich TE, Markowitz JS. A discriminative genotypic method for detecting CES1A1 and CES1A2/CES1A3 genetic variants. Pharmacogenetics & Genomics 2012; 22:215-8. (PMID: 22237548)
Zhu HJ, Appel DI, Gründemann D, Markowitz JS. Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochemistry 2010;114:142–9. (PMID: 20402963)
Zhu H-J, Patrick KS, Yuan H-J, Wang J-S, Donovan JL, DeVane, CL, Malcolm R, Johnson JA, Youngblood GL, Sweet DH, Langaee TY, Markowitz JS. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: Clinical significance and molecular basis. Am J Hum Genetics 2008;82:1241-48. (PMID: 18485328)
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