Stephan Jahn, Ph.D.

Stephan Jahn

Research Associate

Medicinal Chemistry

OFFICE: MSB P6-32

EMAIL: scjahn@cop.ufl.edu

PHONE: 352-273-7709

 

Education

  • Doctorate of Philosophy in Medical Sciences, Physiology and Pharmacology Concentration, University of Florida College of Medicine, Gainesville, FL, 2013
    Dissertation: Overactive Cdk2 in the Progression and Treatment of Cancer
  • Certificate in Teaching with Technology, University of Florida Graduate School, Gainesville, FL, 2012
  • Certificate in Pedagogy, University of Florida Graduate School, Gainesville, FL, 2011
  • Certificate in European Studies, Lille Catholic University, Lille, France, 2008
  • Bachelor of Science in Biochemistry, Saginaw Valley State University, University Center, MI, 2008         
    Summa Cum Laude, Honors Program
    Thesis:  Completing the Cycle:  Formation of Cloud Point Depressants from Glycerin Obtained in the Production of Biodiesel

Curriculum Vitae

 

Research Interests

  • Investigating various aspects of the metabolism of dichloroacetate by GSTZ1, including:
  • the role of miRNAs in regulating GSTZ1 expression during human development
  • the effect of extrahepatic GSTZ1 expression on dichloroacetate clearance
  • resistance to dichloroacetate by solid tumors that express GSTZ1
  • the concentration of chloride ion in varied organ tissues and tumors, and its impact on dichloroacetate metabolism.

Publications

  1. James MO, Jahn SC, Zhong G, Smeltz MG, Hu Z, Stacpoole PW.  Therapeutic Applications of Dichloroacetate and the Role of Glutathione Transferase Zeta-1.  Pharmacol Ther 170:166-80 (2017)
  2. Jahn SC, Solaymen MH, Lorenzo JL, Langaee T, Stacpoole PW, James MO.  GSTZ1 Expression and Chloride Concentrations Modulate Sensitivity of Cancer Cells to Dichloroacetate.  Biochim Biophys Acta 1860(6):1202-10 (2016) [ denotes undergraduate]
  3. Jahn SC, Biel MB, Sudhan DR, Wiggins JM, Hughes VS.  A Summer Course in Cancer for High School Students – Lessons Taught and Lessons Learned. J Postdoctoral Res 3(11):15-23 (2015)
  4. Jahn SC, Rowland-Faux L, Stacpoole PW, James MO.  Chloride Concentrations in Human Hepatic Cytosol and Mitochondria Are a Function of Age.  Biochem Biophys Res Commun 459(3):463-8 (2015)
  5. Ferreira RB, Law ME, Jahn SC, Davis BJ, Heldermon CD, Reinhard MK, Castellano RK, Law BK.  Novel Agents that Downregulate EGFR, HER2, and HER3 in Parallel. Oncotarget 6(12):10445-59 (2015)
  6. Jahn SC, Law ME, Corsino PE, Davis BJ, Harrison JK, Law BK. Signaling Mechanisms that Suppress the Cytostatic Actions of Rapamycin. PLOS ONE  9(6):e99927 (2014)
  7. Jahn SC.  Vetting the Internet’s Favorite Cancer Cures. J Postdoctoral Res. 2(5):24-36 (2014) [Review Article]
  8. Jahn SC, Law ME, Corsino PE, Rowe TC, Davis BJ, Law BK. Assembly, Activation, and Substrate Specificity of Cyclin D1/Cdk2 Complexes. Biochemistry 52(20):3489-501 (2013)
  9. Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, Liao D. Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening are Potent Anticancer Agents. Mol. Cancer Ther. 12(5):610-20 (2013)
  10. Jahn SC, Corsino PE, Davis BJ, Law ME, Norgaard P, Law BK.  Constitutive Cdk2 Activation Promotes Aneuploidy While Altering the Spindle Assembly and Tetraploidy Checkpoints. J Cell Sci. 126(Pt 5):1207-17 (2013)
  11. Jahn SC*, Law ME*, Corsino PE, Parker NN, Pham K, Davis BJ, Lu J, Law BK. An In Vivo Model of Epithelial to Mesenchymal Transition Reveals a Mitogenic Switch. Cancer Letters. 326(2):183-90 (2012) [* denotes co-first authors]
  12. Law M, Corsino P, Jahn S, Davis B, Chen S, Patel B, Pham K, Lu J, Sheppard B, Norgaard P, Hong J, Higgins P, Kim J, Luesch H, Law B. Glucocorticoids and Histone Deacetylase Inhibitors Cooperate to Block the Invasiveness of Basal-like Breast Cancer Cells through Novel Mechanisms. Oncogene 32(10):1316-29 (2012)
  13. Jahn S, Law M, Corsino P, Law B. TGF-beta Antiproliferative Effects in Tumor Suppression. Front Biosci. 4:749-66 (2012) [Review Article]
  14. Jayandharan G, Aslanidi G, Martino A, Jahn S, Perrin G, Herzog R, Srivastava A. Activation of the NF-{kappa}B Pathway by Adeno-Associated Virus (AAV) Vectors and its Implications in Immune Response and Gene Therapy. PNAS 108(9):3743-8 (2010)