Qi-Yin Chen, Ph.D.

Qi-Yin Chen

Assistant Scientist

Medicinal Chemistry

OFFICE: MSB P5-26

EMAIL: chenqyufl@ufl.edu

PHONE: 352-273-7739

 

EDUCATION

  • B.S., Henan Normal University, China
  • M.S., Central South University of Technology (Central South University), China
  • Ph.D., Institute of Chemistry, Chinese Academy of Science, China
  • Postdoctoral fellow: University of Florida and Tokyo University of Science

BIOGRAPHICAL SKETCH

QiYin Chen, Ph.D., serves as a research scientist in Dr. Hendrik Luesch’s group in the department of Medicinal Chemistry.  During his postdocs, he worked on the synthesis of bioprobes (natural product based), total synthesis of natural products, methodology of organic synthesis and the synthesis of pharmaceutical molecules. In 2008, he joined Dr. Luesch’s group where his research includes total synthesis and modification of (marine) natural products and the synthesis of pharmaceutical molecules.

RESEARCH INTERESTS

Total synthesis of natural products, synthesis of pharmaceutical compounds, synthesis of bioprobes, drug discovery and development.

SELECTED PUBLICATIONS

Weijing Cai, Qi-Yin Chen (equal contribution), Long Dang, Hendrik Luesch, Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors ACS Medicinal Chemistry Letter 2017, 8, 1007-1012.

Ping Wu, Weijing Cai, Qi-Yin Chen, Senhan Xu, Ruwen Yin, Yingxia Li, Wei Zhang, Hendrik Luesch, Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product. Org. Lett. 2016, 18, 5400-5403.

Danmeng Luo, Qi-Yin Chen and Hendrik Luesch, Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and in Vitro Biological Evaluation in Model Systems for Pulmonary Diseases Org. Chem. 2016, 81, 532-544.

Qi-Yin Chen, Yanxia Liu and Hendrik Luesch, Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity J. Med. Chem. 2014, 57, 3011-3029.

Qi-Yin Chen, Yanxia Liu and Hendrik Luesch, Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity, ACS Med. Chem. Lett. 2011, 2, 861-865.

Yujiro Hayashi, Seiji Aratake, Yoshinaga Imai, Kazuhiro Hibino, Qi-Yin Chen, Junichiro Yamaguchi, Tadafumi Uchimaru, Direct Asymmetric -Amination of Cyclic Ketones Catalyzed by Siloxyproline, Chemistry – An Asian Journal, 2008, 3, 225-232.

Alan R. Katritzky, Qi-Yin Chen and Srinivasa R. Tala, Convenient Preparation of Azo-Dye-Labelled Amino Acids and Amines, Org. Biomol. Chem., 2008, 6, 2400-2404.    

Alan R. Katritzky, Srinivasa R. Tala, Hong Lu, Anatoliy V. Vakulenko, Qi-Yin Chen, Jothilingam Sivapackiam, Keyur Pandya, Shibo Jiang, and Asim K. Debnath, Design, Synthesis, and Structure-Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 Entry Inhibitors, J. Med. Chem. 2009, 52, 7631–7639.

PATENTS

Hendrik Luesch, Qi-Yin Chen, “Macrocyclic therapeutic agents, methods of manufacture, and methods of treatment.” Application No. PCT/US2015/016743, Feb 20, 2015; Publication No. WO2015127161 A1, Aug 27, 2015 and US20170057996 A1. University of Florida.