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Pharmaceutics

The Department of Pharmaceutics is located in the University of Florida, J. Hillis Miller Health Center, Room P3-20, 1600 SW Archer Rd., a complex that includes the Colleges of Pharmacy, Medicine, Nursing, Health Related Professions, Dentistry, and Veterinary Medicine, Shands Hospital, and the Veterans Administration Medical Center. The variety of disciplines in the health science complex guarantees a stimulating scientific environment..

Research in the Pharmaceutics Department encompasses basic, applied, and clinical investigations in (i) pharmacokinetics/ biopharmaceutics, (ii) pharmaceutical analysis, (iii) pharmaceutical biotechnology and drug delivery, (iv) herbal medicine. In addition to teaching, all faculty members are involved in collaborative research projects with clinical and other basic scientists within the Health Center or on campus. Many maintain collaborative ties with scientists in other universities and the pharmaceutical industry worldwide.

Student Profile: Johannes Kast


Faculty Spotlight

Lawrence J. Lesko, Ph.D., F.C.P.Professor

Larry Lesko, Ph.D., leads UF’s new pharmacometrics and systems pharmacology initiative in the interdisciplinary Institute of Therapeutic Innovation at the UF Research and Academic Center
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Additional Faculty

Meet our award-winning faculty and those faculty serving in adjunct, emeritus and facilitator roles.

AAPS

American Association of Pharmaceutical Scientists

Student Chapter

News

30th Annual Research Showcase celebrates milestone year with record participation

A record 89 poster entries and a keynote address about how technology is transforming clinical drug development highlighted the College of Pharmacy’s 30th Annual Research Showcase event on Feb. 17.

The day of excitement and discovery offered an opportunity for professional pharmacy students, graduate students and postdoctoral fellows to share research findings and compete for awards in either oral or poster competitions.

Latoy Waite, right, competed in her first Research Showcase poster competition

For second-year Pharm.D. student Latoy Waite, Research Showcase presented the first opportunity for her to compete in a research poster competition. Waite studies in the research lab of Hendrik Luesch, Ph.D., professor and chair of medicinal chemistry and the Debbie and Sylvia DeSantis Chair in Natural Products Drug Discovery and Development. Her research poster featured two different drug discovery approaches involving sponges from a marine environment, with the idea of testing the sponges to explore if they have bioactivity against cancer cells and persistent bacteria.

“One of the reasons why I decided to attend the University of Florida’s College of Pharmacy is that we have many opportunities to get involved with research,” Waite said. “Events like this allow me to share my research with others and gain valuable experience in improving my presentation skills.”

Johannes Kast presents his poster on how medications work in space.

Johannes Kast, a fifth-year Ph.D. student in the department of pharmaceutics, competed in his fourth Research Showcase this year. His poster examined how medications work in space—specifically how the efficacy of amoxicillin could be impaired during space missions. Through modeling and simulation, he found that the bacterial burden in space may be higher due to increased antibiotic resistance and deceased amoxicillin concentrations in the body.

Kast has regularly competed in Research Showcase because it makes him a better scientist.

“Since Research Showcase is a college-wide event, you have scientists outside your field visiting your poster, and you are challenged to communicate your research in a way that they understand it,” Kast said. “Researchers are always presenting their work, and the best way to improve your communication skills is to compete in events such as Research Showcase.”

Edmundo Muniz, M.D., Ph.D., CEO of Certara, a company offering technology and consulting services for optimizing drug development and improving health outcomes, offered insight into the intersection of technology and biology in his keynote remarks. He defined a paradigm shift underway in biology, including drug discovery, development and use, where technology is radically transforming the process of knowledge generation and decision-making.

Dr. Edmundo Muniz, CEO of Certara, delivered the keynote address.

“Rapid advancements in information technology and computer processing power are transforming our understanding of biology to revolutionize drug discovery, development and patient care as never before,” Muniz said. “In the future, models and simulations will drive decisions, not small numbers of real-life patients, and drug development will become largely virtualized.”

Muniz predicted that technology will reduce the role of humans in clinical trials. Furthermore, “one size fits all” drug development will give way to personalized medicine and individualized care. He also told the audience that translational science will be required to show not just efficacy and safety, but meaningful value to the healthcare system. He added that pharmaceutical drug development will shift from a predominantly biological scientific focus to a hybrid with a strong focus on technology.

Adding to the significance of this year’s event was the 30th anniversary milestone. The Annual Research Showcase began under the leadership of former UF College of Pharmacy Dean Michael Schwartz, Ph.D., who saw the event as an opportunity to bring greater visibility to the college’s research efforts and promote collaboration among departments. A video from College of Pharmacy alumni who had participated in previous Research Showcase events was shown to commemorate the milestone year.

VIEW PHOTOS OF THE EVENT

Congratulatory Video on 30 Years of Research Showcase

Oral Competition Winners

Finalists and winners of the oral competition.

Millard Senior Division Winner: Weijing Cai, Medicinal Chemistry
Development of Apratoxins, Marine-Derived Anticancer Agents with Novel Effects on Growth Factor Signaling

Millard Senior Division Finalists:

  • Fatma Al-Awadhi, Medicinal Chemistry Discovery of Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer
  • Kyle Kelly, Pharmacodynamics Restoring Working Memory Performance in Aged Rats by Altering Subunit-Specific

Junior Division Winner: Yalun Tan, Pharmacodynamics
Oxytocin Receptor Expressing Neurons within the Prefontal Cortex Send subcortical Projections and Control Social Novelty Preference

Junior Division Finalist:

  • Ahmed Elshikha, Pharmaceutics Alpha 1 Antitrypsin Ameliorates Lupus Development in Mouse Models
  • Danmeng Luo, Medicinal Chemistry Discovery and Development of the Potent Marine-Derived Elastase Inhibitor Luyngbyastatin 7: SAR Studies, Total Synthesis, and Biological Evaluation

Levitt Division Winner: Wei Wang, Pharmaceutical Outcomes and Policy
Association of Chronic Hepatitis C Virus Infection and the Risk of Cardiovascular Disease in the U.S.

Junior Division Finalist:

  • Juan Hincapie-Castillo, Pharmaceutical Outcomes and Policy Development of a Predictive Model for Uncontrolled Post-Operative Pain in the Inpatient Setting Using Electronic Health Record Data

Oral Competition Judges

  • Joshua Brown, Pharm.D., Ph.D., assistant professor of pharmaceutical outcomes and policy
  • Rhonda Cooper-DeHoff, Pharm.D., M.S., associate professor of pharmacotherapy and translational research
  • Christopher Delcher, Ph.D., assistant professor of health outcomes and policy
  • Chenglong Li, Ph.D., professor of medicinal chemistry
  • Rene Soria-Saucedo, M.D., Ph.D., M.P.H., assistant professor of pharmaceutical outcomes and policy
  • Gonzalo Torres, Ph.D., assistant professor of pharmacology
  • Edmundo Muniz, M.D., Ph.D., CEO, Certara

 

Poster Competition Winners

Ph.D. Category

Impact of Genetic Variants in ara-C Metabolic Pathway Genes on Intracellular Ara-CTP Levels and DNA Synthesis Inhibition in AML Patients
Presenter: Abderlrahman Elsayed

Multi-site Lactonization introduced by a Distributive ATP Grasp Ligase in Microviridin Biosynthesis
Presenter: Yi Zhang

Chronically Increased Maternal Cortisol Concentrations in Late Gestation Alters Fetal ECG at Birth
Presenter: Andrew Antolic

Postdoc Category

Genome Wide Association Study to Identify Pharmacogenomic Variants Associated with Chlorthalidone Induced Glucose Change in African Americans
Presenter: Sonal Singh

Pharm.D. Category

STAT6 and ADRB2 Variation in LABA-associated Treatment Failure
Presenter: Elizabeth Shald

Poster Competition Judges

  • Meghan Arwood, Pharm.D., clinical assistant professor of pharmacotherapy and translational research
  • Adriaan Bruijnzeel, professor of psychiatry
  • Ashley Brown, Ph.D., assistant professor of medicine
  • Rhonda Cooper-DeHoff, Pharm.D., M.S., associate professor of pharmacotherapy and translational research
  • Christopher Delcher, Ph.D., assistant professor of health outcomes and policy
  • Kenneth Klinker, Pharm.D., clinical associate professor of pharmacotherapy and translational research
  • Bin Liu, Ph.D., associate professor of pharmacodynamics
  • William Millard, Ph.D., professor emeritus of pharmacodynamics
  • Cary Mobley, Ph.D., clinical associate professor of pharmaceutics
  • Joanna Peris, Ph.D., associate professor of pharmacodynamics
  • Deborah Scheuer, Ph.D., associate professor of physiology and functional genomics
  • Thomas Schmittgen, Ph.D., professor of pharmaceutics
  • Chengguo Xing, Ph.D., professor of medicinal chemistry
  • Lihui Yuan, Pharm.D., Ph.D., clinical lecturer of pharmacodynamics

 

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Dr. Derendorf invited to serve on a NASA Expert Review Panel

Derendorf

Hartmut Derendorf, Ph.D.

Hartmut Derendorf, Ph.D., a distinguished professor of pharmaceutics and the V. Ravi Chandran Professor in Pharmaceutical Sciences, has been invited to serve on an Expert Review Panel at NASA. The panel will review the Pharmaceutical Research Plan developed by the NASA Human Research Program’s Exploration Medical Capabilities Element Pharmacy Team. The plan details a research pathway designed to identify and develop a safe and effective medication formulary for future long-duration exploration spaceflight missions.

Joining Derendorf on the panel are five prominent researchers in the field of pharmaceutical science and medicine who will review the research plan and offer suggestions for achieving successful research outcomes. The panel will meet for the first time in March at the Johnson Space Center in Houston.

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