- The Scripps Research Institute, Scripps Florida, Senior Research Associate/Scientist, Chemistry and Cancer Biology, 2009-2012
- UT Southwestern Medical Center, Dallas, TX Postdoctoral Scholar, Biochemistry/Translational Research/Internal Medicine, 2005- 2009
- California Institute of Technology, Pasadena, CA Ph.D., Bioorganic Chemistry, 2005
- Wayne State University, Detroit, MI M.S., Organic Chemistry, 2000
- Peking University, Beijing, P. R. China B.S., Polymer Chemistry, 1991
Cindy Qi, Ph.D., an assistant professor of medicinal chemistry, received her B.S. in Polymer Chemistry from Peking University, and an M.S. in Organic Chemistry from Wayne State University. After completing her Ph.D. training in bioorganic chemistry with Dr. Richard Roberts at Caltech, Dr. Qi pursued postdoctoral studies of apoptosis in cancer research at UT Southwestern Medical Center under the mentorship of Dr. Xiaodong Wang. She then gained extensive expertise in peptoid library screening at Scripps Florida working with Dr. Thomas Kodadek as senior scientist. She has conducted research in the areas of organic synthesis, biochemistry, chemical biology and cancer biology. These opportunities have allowed her to address interesting and novel questions through a variety of biochemical approaches, collectively leading to coherent answers to these problems. These projects will provide a better understanding of the underlying mechanisms of certain diseases, along with elucidating regulatory functions of novel small molecules obtained from large peptoid library screening. Together, these studies will lead to novel and highly specific methods for the prevention, diagnosis and treatment of human diseases.
Conduct research at the interface between Chemistry and Biology with focus on Medicinal Chemistry. Develop innovative technologies in peptoid synthesis and application, peptide and protein engineering, and microarray high through-put screening. Address biologically significant problems in chemical biology and cancer biology, including signaling pathways, cancer pathogenesis and significant functional roles of regulatory molecules in those biological processes.
Current Areas of Research:
- Develop new methods to synthesize cyclic and conformation constrained peptoids.
- Probe complex signaling pathways such as apoptosis with regulatory molecules from large peptoid library screening and elucidate their roles in cancer biology.
- Develop facile peptoid and microarray screening to rapid identify high affinity GPCR ligands from large combinatorial library using multi-color quantum dots labeled cell-based screening and microarray technology.
Qi Lab Group
Student Lab Members
2012- Member, UF Shands Cancer Center
2012- Member, American Association of Colleges of Pharmacy
2012- ASBMB member
2012- President, Biotech Club at Scripps Florida
2011 – Distinguished Lecture Series Chair, Scripps Florida Society of Research
2010 – Treasurer, Scripps Florida Society of Research Fellows
2007 – Member, Sigma Xi
2006 – President, Chinese Student and Scholar Assoc. at UTSW Medical Center
2006 – Member, Career Committee, Postdoctoral Assoc. at UTSW Medical Center
2006 – Board Member, Chinese Assoc. for Science and Technology (CAST), Texas
1998 – Member, American Chemical Society
1997 – Member, Phi Lambda Upsilon
• Junjie Fu, Timothy Lee and Xin Qi, “Rapid Identification of High-affinity GPCR Ligands from Large Combinatorial Library Using Multi-color Quantum Dots Labeled Cell-based Screening”, Future Medicinal Chemistry, 2014, just accepted.
• Jia Lu, Vivian Wong, Yi Zhang, Trung Tran, Liang Zhao, Amy Xia, Tianbing Xia, and Xin Qi, “Distinct Conformational Transition Patterns of Non-coding 7SK snRNA and HIV TAR RNAs Upon Tat Binding”, Biochemistry, 2014, 53(4), 675-681. DOI: 10.1021/bi401131z.
• Jia Lu, Liang Zhao, Amy Xia, Tianbing Xia, and Xin Qi, “Dissect Conformational Distribution and Drug-Induced Population Shift of Prokaryotic rRNA A-Site“, Biochemistry, 2013, 52, 1651-1653.
• Xin Qi, Tianbing Xia, “Structure, Dynamics, and Mechanism of Lead Dependent Ribozyme,” BioMolecular Concepts, 2011, 2, 305-314.
• Jia Lu, Beena M. Kadakkuzha, Liang Zhao, Martin Fan, Xin Qi, and Tianbing Xia, “Dynamic Ensemble View of the Conformational Landscape of HIV-1 TAR RNA and Allosteric Recognition,” Biochemistry, 2011, 50, 5042-5057.
• Xin Qi, John Astle, Thomas Kodadek, “Rapid Identification of Orexin Receptor Binding Ligands using Cell-based Screening Accelerated with Magnetic Beads,” Mol. BioSyst. 2010, 6, 102-107. PMID: 20024071
• Xin Qi, Tianbing Xia, Richard Roberts, “Acridine-N Peptide Conjugates Display Enhanced Affinity and Specificity to Box B RNA Targets,” Biochemistry, 2010, 49, 5782-5789. DOI: 10.1021/bi100634h
• Xin Qi, Lai Wang, Fenghe Du, “Novel Small Molecules Relieve Prothymosin α- Mediated Inhibition of Apoptosome Formation by Blocking its Interaction with Apaf-1,” Biochemistry, 2010, 49, 1923-1930. NIHMS: 178260
• Shelley R. Starck, Yongkai Ow, Vivian Jiang, Maria Tokuyama, Mark Rivera, Xin Qi, Richard W. Roberts, Nilabh Shastri, “A Distinct Translation Initiation Mechanism Generates Cryptic Peptides for Immune Surveillance,” PLoS One 2008, 3(10), e3460. PMCID: PMC 2565129.
• Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T. Takahashi, Alexander Varshavsky, “The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators” Nature 2005, 437, 981-986.
• Shelley R. Starck, Xin Qi, Brett N. Olsen, Richard W. Roberts, “The Puromycin Route to Assess Stereo- and Regiochemical Constraints on Peptide Bond Formation in Eukaryotic Ribosomes” J. Am. Chem. Soc. 2003, 125, 8090-8091.
• Xin Qi, John Montgomery, “New Three Component Synthesis of 1,3-Dienes Employing Nickel Catalysis” J. Org. Chem. 1999, 64, 9310-9313.
• Xin Qi, John Montgomery, “Preparation of 1,3-Dienes by Nickel-Catalyzed Three-Component Couplings” Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26, 1999. ORGN-293.