- The Scripps Research Institute, Scripps Florida, Senior Research Associate/Scientist, Chemistry and Cancer Biology, 2009-2012
- UT Southwestern Medical Center, Dallas, TX Postdoctoral Scholar, Biochemistry/Translational Research/Internal Medicine, 2005- 2009
- California Institute of Technology, Pasadena, CA Ph.D., Bioorganic Chemistry, 2005
- Wayne State University, Detroit, MI M.S., Organic Chemistry, 2000
- Peking University, Beijing, P. R. China B.S., Polymer Chemistry, 1991
Cindy Qi, Ph.D., an assistant professor of medicinal chemistry, received her B.S. in Polymer Chemistry from Peking University, and an M.S. in Organic Chemistry from Wayne State University. After completing her Ph.D. training in bioorganic chemistry with Dr. Richard Roberts at Caltech, Dr. Qi pursued postdoctoral studies of apoptosis in cancer research at UT Southwestern Medical Center under the mentorship of Dr. Xiaodong Wang. She then gained extensive expertise in peptoid library screening at Scripps Florida working with Dr. Thomas Kodadek as senior scientist. She has conducted research in the areas of organic synthesis, biochemistry, chemical biology and cancer biology. These opportunities have allowed her to address interesting and novel questions through a variety of biochemical approaches, collectively leading to coherent answers to these problems. These projects will provide a better understanding of the underlying mechanisms of certain diseases, along with elucidating regulatory functions of novel small molecules obtained from large peptoid library screening. Together, these studies will lead to novel and highly specific methods for the prevention, diagnosis and treatment of human diseases.
Conduct research at the interface between Chemistry and Biology with focus on Medicinal Chemistry. Develop innovative technologies in peptoid synthesis and application, peptide and protein engineering, and microarray high through-put screening. Address biologically significant problems in chemical biology and cancer biology, including signaling pathways, cancer pathogenesis and significant functional roles of regulatory molecules in those biological processes.
Current Areas of Research:
- Develop new methods to synthesize cyclic and conformation constrained peptoids.
- Probe complex signaling pathways such as apoptosis with regulatory molecules from large peptoid library screening and elucidate their roles in cancer biology.
- Develop facile peptoid and microarray screening to rapid identify high affinity GPCR ligands from large combinatorial library using multi-color quantum dots labeled cell-based screening and microarray technology.
Qi Lab Group
Student Lab Members
- 2013- Member, American Heart Association
- 2013- Member, UF Clinical and Translational Science Institute (CTSI)
- 2013- Member, UF Emerging Pathogens Institute (EPI)
- 2013- Member, UF Center for Natural Products, Drug Discovery and Development (CNPD3)
- 2012- Member, American Society for Biochemistry and Molecular Biology
- 2012- President, Biotech Club at Scripps Florida
- 2012- Member, UF Health Cancer Center
- 2012- Member, American Association of Colleges of Pharmacy
- 2011- Distinguished Lecture Series Chair, Scripps Florida Society of Research Fellows
- 2010- Treasurer, Scripps Florida Society of Research Fellows
- 2007- Member, Sigma Xi
- 2006- President, Chinese Student and Scholar Association at UTSW Medical Center
- 1998- Member, American Chemical Society
- 1997- Member, Phi Lambda Upsilon
- Junjie Fu, Amy Xia and Xin Qi*, “Identification of Novel Peptoid Agonists of Fibroblast Growth Factor Receptor Using Microarray-based Screening”, Med. Chem. Comm., Royal Society of Chemistry, 2016, DOI: 10.1039/C6MD00121A.
- Bereket Mochona, Xin Qi, Suresh Euynni, Donald Sikazwi, Nelly Mateeva, Karam Soliman, “Design and evaluation of novel oxadiazole derivatives as potential prostate cancer agents”, Bioorg. Med. Chem. Lett., 2016, DOI:10.1016/j.bmcl.2016.04.058.
- Ravil Khaybullin, Xiao Liang, Katherine Cisneros and Xin Qi*, “Synthesis and Anti-cancer Evaluation of Complex Unsaturated Isosteviol Derived Triazole Conjugates”, Future Medicinal Chemistry, 2015, doi:10.4155/fmc.15.158.
- Peter Vertesaljai, Iryna O. Lebedyeva, Alexander A. Oliferenko, Xin Qi, Junjie Fu, David A. Ostrov, Abdullah M. Asiri, C. Dennis Hall, Alan Katritzky, “Mimicking a Proline Tripeptide with Pyrazolidines and a Cyclopentane Linker”, Tetrahedron Letters, 2015, 56, 6653-6655.
- Junjie Fu, Ravil Khaybullin, Yanping Zhang, Amy Xia, and Xin Qi*, “Gene Expression Profiling Leads to Discovery of Correlation of Matrix Metalloproteinase 11 and Heparanase 2 in Breast Cancer Progression”, BMC Cancer, 2015, 15:473, doi:10.1186/s12885-015-1410-y
- Jia Lu, Larry Nguyen, Liang Zhao, Tianbing Xia, and Xin Qi*, “Cyclic Mimic of HIV Tat Differentiates Similar TAR RNAs Based on Distinct Dynamic Behaviors”, Biochemistry, 2015, 54 (23), 3687–3693.
- Ravil Khaybullin, Xiao Liang, and Xin Qi*, “(S)-N-(N-(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)sulfamoyl)-5-oxopyrrolidine-2-carboxamide”. Molbank, 2015, M864, doi:10.3390/M864.
- Xiao Liang, Ravil Khaybullin, Junjie Fu, Kevin Goncalves, Amy Xia, and Xin Qi*, “Genetic Code Expansion using Aminoacylated Orthogonal tRNAs in Conjunction with Aminoacyl Sulfamides”, Int J of Recent Technology and Engineering, 2015, 3 (6), 78-82.
- Junjie Fu, Ravil Khaybullin, Xiao Liang, Madeleine Morin, Amy Xia, Anderson Yeh, Xin Qi, “Discovery of Gene Regulation Pattern in Lung Cancer by Gene Expression Profiling Using Human Tissues”, Genomics Data, 2015, 3, 112-115.
- Ravil N. Khaybullin, Mei Zhang, Junjie Fu, Xiao Liang, Tammy Li, Alan R. Katritzky, Paul Okunieff and Xin Qi, “Design and Synthesis of Isosteviol Triazole Conjugates for Cancer Therapy”, Molecules, 2014, 19 (11), 18676-18689.
- Junjie Fu, William Allen, Amy Xia, Zhuofan Ma and Xin Qi, “Identification of Biomarkers in Breast Cancer by Gene Expression Profiling Using Human Tissues”, Genomics Data, 2014,2, 299-301
- Junjie Fu, Timothy Lee and Xin Qi, “The Identification of High-affinity GPCR Ligands from Large Combinatorial Library Using Multi-color Quantum Dots Labeled Cell-based Screening”, Future Medicinal Chemistry, 2014,6(7), 809-823.
- Jia Lu, Vivian Wong, Yi Zhang, Trung Tran, Liang Zhao, Amy Xia, Tianbing Xia, and Xin Qi, “Distinct Conformational Transition Patterns of Non-coding 7SK snRNA and HIV TAR RNAs Upon Tat Binding”, Biochemistry, 2014, 53(4), 675-681. DOI: 10.1021/bi401131z
- Jia Lu, Liang Zhao, Amy Xia, Tianbing Xia, and Xin Qi, “Dissect Conformational Distribution and Drug-Induced Population Shift of Prokaryotic rRNA A-Site”, Biochemistry, 2013, 52, 1651-1653. DOI: 10.1021/bi400053s
- Xin Qi, Tianbing Xia, “Structure, Dynamics, and Mechanism of Lead Dependent Ribozyme”, BioMolecular Concepts, 2011, 2, 305-314.
- Jia Lu, Beena M. Kadakkuzha, Liang Zhao, Martin Fan, Xin Qi, and Tianbing Xia, “Dynamic Ensemble View of the Conformational Landscape of HIV-1 TAR RNA and Allosteric Recognition”, Biochemistry, 2011, 50, 5042-5057.
- Xin Qi, John Astle, Thomas Kodadek, “Rapid Identification of Orexin Receptor Binding Ligands using Cell-based Screening Accelerated with Magnetic Beads”, Mol. BioSyst. 2010, 6, 102-107.PMID: 20024071
- Xin Qi, Tianbing Xia, Richard Roberts, “Acridine-N Peptide Conjugates Display Enhanced Affinity and Specificity to Box B RNA Targets”, Biochemistry, 2010, 49, 5782-5789. DOI: 10.1021/bi100634h
- Xin Qi, Lai Wang, Fenghe Du, “Novel Small Molecules RelieveProthymosin α- Mediated Inhibition of Apoptosome Formation by Blocking its Interaction with Apaf-1”, Biochemistry, 2010, 49, 1923-1930. NIHMS: 178260
- Shelley R. Starck, Yongkai Ow, Vivian Jiang, Maria Tokuyama, Mark Rivera, Xin Qi, Richard W. Roberts, Nilabh Shastri, “A Distinct Translation Initiation Mechanism Generates Cryptic Peptides for Immune Surveillance”,PLoS One 2008, 3(10), e3460.PMCID: PMC 2565129.
- Rong‑Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T. Takahashi, Alexander Varshavsky, “The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators” Nature 2005, 437, 981-986.
- Shelley R. Starck, Xin Qi, Brett N. Olsen, Richard W. Roberts, “The Puromycin Route to Assess Stereo- and Regiochemical Constraints on Peptide Bond Formation in Eukaryotic Ribosomes” J. Am. Chem. Soc. 2003, 125, 8090-8091.
- Xin Qi, John Montgomery, “New Three Component Synthesis of 1,3-Dienes Employing Nickel Catalysis” J. Org. Chem. 1999, 64, 9310-9313.