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Stephan Schmidt, Ph.D.

Stephan Schmidt

Associate Director


OFFICE: 6550 Sanger Road, Office 467, Orlando FL 32827


PHONE: 407-313-7012

CV: Link to CV



  • Ph.D. Pharmaceutical Sciences, University of Florida, Gainesville, FL, 2008
  • B.S. Pharmaceutical Sciences, Friedrich-Alexander University, Erlangen, Germany, 2004

Biographical Sketch

Dr. Schmidt is an Assistant Professor & Associate Director of the Center for Pharmacometrics and Systems Pharmacology (CPSP) in Lake Nona (Orlando). He received his B.S. in Pharmaceutical Sciences from the Friedrich-Alexander University in Erlangen, Germany in 2003 and his license to practice as a pharmacist in Germany in 2005. He received his Ph.D. from the University of Florida under the supervision of Dr. Hartmut Derendorf in 2008, before completing a 3 year postdoctoral fellowship under the supervision of Prof. Meindert Danhof in the Division of Pharmacology at the Leiden/Amsterdam Center for Drug Research in The Netherlands. During his postdoctoral fellowship, Dr. Schmidt was also a member of the Dutch Top Institute Pharma PK-PD modeling platform.

His research focuses on the application of quantitative (Pharmacometrics and Systems Pharmacology) tools to address clinically relevant research questions in the area of antimicrobial chemotherapy, pediatrics, diabetes, cardiovascular safety and post-menopausal osteoporosis. Dr. Schmidt published more than 40 peer-reviewed articles in highly respected journals in the clinical pharmacology arena including Clinical Pharmacology & Therapeutics, CPT:PSP, the British Journal of Clinical Pharmacology, the Journal of Pharmaceutical Sciences, Clinical Pharmacokinetics, and Antimicrobial Agents and Chemotherapy. He also published 4 book chapters on the application of quantitative analysis techniques in various therapeutic areas and is the editor of a book entitled, “Applied Pharmacometrics”, published in 2014 as part of an AAPS series on advancing Pharmaceutical Sciences.

Dr. Schmidt received the Paul Ehrlich Society for Chemotherapy Thesis Award for his work on “Pharmacokinetics/Pharmacodynamics of oxazolidinones and beta-lactams” in 2010, the University of Florida Clinical Translational Science Institute Junior Faculty Pilot Program Award in 2012, the University of Florida Excellence Award for Assistant Professors in 2013, the Tanabe Young Investigator Award from the American College of Clinical Pharmacology (ACCP) in 2016 and was named International Educator of the Year (Junior Faculty Category) of the College of Pharmacy at the University of Florida in 2014. He also serves as the Chair of the BPS Special Interest Group on PK/PD and Systems Pharmacology of the International Pharmaceutical Federation (Federation Internationale Pharmaceutique, FIP) as well as the Vice Chair of the Systems Pharmacology Community for the American Society for Clinical Pharmacology and Therapeutics (ASCPT). Dr. Schmidt is a Section Editor in the area of clinical pharmacology for the European Journal of Pharmaceutical Sciences and serves as an Editorial Board Member for the Journal of Clinical Pharmacology as well as ASCPT’s Pharmacometrics and Systems Pharmacology journal (CPT Pharmacometrics Syst Pharmacol).


  • International Society of Pharmacometrics (ISoP)
  • American Society for Clinical Pharmacology and Therapeutics (ASCPT)
  • American Association of Colleges of Pharmacy (AACP)
  • Paul-Ehrlich Society for Chemotherapy (PEG)
  • American College of Clinical Pharmacology (ACCP)
  • American Association of Pharmaceutical Scientists (AAPS)

He published his work in 10 peer reviewed journals including the British Journal of Clinical Pharmacology, the Journal of Pharmaceutical Sciences, Clinical Pharmacokinetics, and Antimicrobial Agents and Chemotherapy. Dr. Schmidt is also the lead author of a book chapter on disease progression analysis, published in 2011 as part of an AAPS series on advancing Pharmaceutical Sciences.

  1. Zheng S, Gaitonde P, Andrew MA, Gibbs MA, Lesko LJ, Schmidt S. Model-based assessment of dosing strategies in children for monoclonal antibodies exhibiting target-mediated drug disposition. CPT Pharmacometrics Syst Pharmacol. 2014; Oct 1;3:e138. doi: 10.1038/psp.2014.38.
  2. Zheng S, Matzneller P, Zeitlinger M, Schmidt S. Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects. Antimicrob Agents Chemother. 2014; 58: 6675-84.
  3. Lesko LJ and Schmidt S. Clinical implementation of genetic testing in medicine: a US regulatory science perspective. Br J Clin Pharmacol. 2014; 77: 606-11
  4. Jiang XL, Zhao P, Barrett JS, Lesko LJ, Schmidt S. Application of physiologically-based pharmacokinetic modeling to predict acetaminophen metabolism & pharmacokinetics in children. CPT Pharmacometrics Syst Pharmacol. 2013 Oct 16;2:e80. doi: 10.1038/psp.2013.55.
  5. Lesko LJ, Zheng S, Schmidt S. Systems approach in risk assessment. Clin Pharmacol Ther. 2013; 93: 413-424