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Robert W. Huigens III, Ph.D.

Robert W. Huigens III

Assistant Professor

Medicinal Chemistry

OFFICE: UF Health Science Center, Medical Science Bldg,1345 Center Drive, Room P5-33

EMAIL: rwhuigens@ufl.edu

PHONE: (352) 273-7718

CV: Link to CV

 

Education

  • B.A. Biology, University of North Carolina at Greensboro, 2000-2003
  • Ph.D. Chemistry, North Carolina State University, 2004-2009
  • American Cancer Society Postdoctoral Fellow, University of Illinois at Urbana-Champaign, 2009-2013

Biographical Sketch

Robert W. Huigens III received his bachelors in biology from the University of North Carolina at Greensboro in 2003 where he first developed an interest in organic synthesis and medicine.  He went on to pursue his graduate studies in organic chemistry at North Carolina State University under the direction of Christian Melander. During his time at North Carolina State University, Dr. Huigens started the biofilm program in the Melander lab while evaluating the biofilm inhibition and dispersal activity of several libraries of ageliferin-inspired small molecules he had synthesized. In 2009, he completed his Ph.D. in chemistry and went on to become an American Cancer Society postdoctoral fellow at the University of Illinois at Urbana-Champaign under the guidance of Paul Hergenrother. As a postdoctoral fellow in the Hergenrother lab, Dr. Huigens developed a rapid approach to generate complex and diverse small molecules from commercially available natural products using various ring-distortion reactions for high-throughput screens in drug discovery efforts (i.e., “Complexity-to-Diversity”). In 2013, he joined the Medicinal Chemistry Department at the University of Florida College of Pharmacy as an assistant professor. His research interests include organic synthesis, drug discovery, medicinal chemistry, antibacterial agents and personalized cancer therapeutics.

Research Interests

The overarching goal of the Huigens lab is to develop novel small molecules that can be used in the treatment of drug-resistant bacterial infections and cancers. Students and postdocs in our group receive training at the interface of chemistry and biology using a combination of synthetic organic chemistry, medicinal chemistry, chemical biology, microbiology and cancer biology approaches. We currently have three major areas of research:

  1. Development of bromophenazine antibacterial agents
  2. Discovery of novel antibiofilm agents
  3. Development of personalized anticancer agents

Huigens Group Members

Professor Robert W. Huigens III – Principal Investigator
Nicholas Paciaroni – Graduate Student (B.S. Chemistry; Clemson University)
Aaron Garrison – Graduate Student (B.A. Biochemistry; University of South Florida)
Yasmeen Abouelhassan – Graduate Student (B.S. Pharmacy; Cairo University)
Akash Basak – Chemistry Graduate Student (M.S. Chemistry; ITT Kanpur)
Chip Norwood – Graduate Student (B.S. Chemistry; East Tennessee State University)
Sahar Alghamdi – Graduate Student (B.S. Pharmacy; King Saud University)
George Sarkis – Chemistry Graduate Student (M.S.; Alexandria University)
Gena Burch – PharmD/PhD Student (B.S. Chemistry; Hillsdale College)
Wilson Wong – Pharmacy Student (B.S. Biochemistry; Florida State University)
Hussain Yousaf – Undergraduate Researcher (Biology Major)
Minh Nguyen – Undergraduate Researcher (Biochemistry Major)
Alexander Valdes – Undergraduate Researcher (Biochemistry Major)

Huigens Lab Photos Summer 2014

University of Florida Affiliations

  1. Chemistry Department (courtesy faculty appointment)
  2. Center for Natural Products, Drug Discovery and Development (CNPD3)
  3. Emerging Pathogens Institute (EPI)
  4. UF Health Cancer Center

Huigens Lab Publications

  • Garrison, A.T.; Bai, F.; Abouelhassan, Y.; Paciaroni, N.G.; Jin, S.; Huigens III, R.W. “Bromophenazine derivatives with potent inhibition, dispersion and eradication activities against Staphylococcus aureus biofilms.” RSC Adv., 2014, accepted manuscript.
  • Abouelhassan, Y.; Garrison, A.T.; Burch, G.M.; Wong, W.; Norwood IV, V. M.; Huigens III, R.W. “Discovery of quinoline small molecules with potent activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy.” Bioorg. Med. Chem. Lett., 2014, 24, 5076-5080.
  • Borrero, N.V.; Bai, F.; Perez, C.; Duong, B.Q.; Rocca, J.R.; Jin, S.; Huigens III, R.W. “Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidisOrg. Biomol. Chem. 2014, 12, 881-886.