- B.A. Biology, University of North Carolina at Greensboro, 2000-2003
- Ph.D. Chemistry, North Carolina State University, 2004-2009
- American Cancer Society Postdoctoral Fellow, University of Illinois at Urbana-Champaign, 2009-2013
Robert W. Huigens III received his bachelors in biology from the University of North Carolina at Greensboro in 2003 where he first developed an interest in organic synthesis and medicine. He went on to pursue his graduate studies in organic chemistry at North Carolina State University under the direction of Christian Melander. During his time at North Carolina State University, Dr. Huigens started the biofilm program in the Melander lab while evaluating the biofilm inhibition and dispersal activity of several libraries of ageliferin-inspired small molecules he had synthesized. In 2009, he completed his Ph.D. in chemistry and went on to become an American Cancer Society postdoctoral fellow at the University of Illinois at Urbana-Champaign under the guidance of Paul Hergenrother. As a postdoctoral fellow in the Hergenrother lab, Dr. Huigens developed a rapid approach to generate complex and diverse small molecules from commercially available natural products using various ring-distortion reactions for high-throughput screens in drug discovery efforts (i.e., “Complexity-to-Diversity”).
In 2013, Dr. Huigens joined the Medicinal Chemistry Department at the University of Florida College of Pharmacy as an assistant professor. His research interests include organic synthesis, drug discovery, medicinal chemistry, chemical biology, antibacterial agents and personalized cancer therapeutics. Recently, Dr. Huigens was the recipient of two Young Investigator Awards from the American Chemical Society (Division of Medicinal Chemistry) and the Center for Biofilm Engineering (Montana State University) for his group’s discovery of novel and potent bacterial biofilm-eradicating agents.
The overarching goal of the Huigens lab is to push back the boundaries of drug discovery using new and innovative strategies to tackle unmet challenges associated with complex molecule synthesis, drug-resistant bacteria and cancer. Students and postdocs in our group receive training at the interface of chemistry and biology using a combination of synthetic organic chemistry, medicinal chemistry, chemical biology and microbiology approaches. We currently have three major areas of research (click on the link below for more on our research programs):
- Developing Innovative Antibacterial Discovery Approaches
- Discovery of Potentiating Agents for Combination Antibacterial Therapies
Huigens Group Members
Professor Robert W. Huigens III – Principal Investigator
Nicholas Paciaroni – Graduate Student (B.S. Chemistry; Clemson University)
Aaron Garrison – Graduate Student (B.A. Biochemistry; University of South Florida)
Yasmeen Abouelhassan – Graduate Student (B.S. Pharmacy; Cairo University)
Akash Basak – Chemistry Graduate Student (M.S. Chemistry; ITT Kanpur)
Chip Norwood – Graduate Student (B.S. Chemistry; East Tennessee State University)
Hongfen Yang – Graduate Student (M.S. Chemistry; Chinese Academy of Sciences)
Gena Burch – PharmD/PhD Student (B.S. Chemistry; Hillsdale College)
Hussain Yousaf – Undergraduate Researcher (Biology Major)
Minh Nguyen – Undergraduate Researcher (Biochemistry Major)
Austin Arnold – Undergraduate Researcher (Chemistry Major)
Grace Hester – Undergraduate Researcher (Interdisciplinary Science Major)
Charles Mock – High School Student Researcher
University of Florida Affiliations
- Chemistry Department (courtesy faculty appointment)
- Center for Natural Products, Drug Discovery and Development (CNPD3)
- Emerging Pathogens Institute (EPI)
- UF Health Cancer Center
Huigens Lab Publications
- Paciaroni, N. G.; Borrero, N. V.; Rocca, J. R., Huigens III, R. W. “Rapid Synthesis of Phenazine-1-Carboxyilc Acid Derived Small Molecules from Diverse Anilines: Privileged Structures for Discovery.” Journal of Medicinal & Organic Chemistry, in press.
- Garrison, A. T.; Abouelhassan, Y.; Kallifidas, D.; Bai, F.; Ukhanova, M.; Mai, V.; Jin, S.; Luesch, H.; Huigens III, R. W. “Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non-Biofilm Cultures and Mycobacterium tuberculosis.” Angew. Chemie Int. Ed., 2015, 54, 14819-14823.
- Basak, A.; Abouelhassan, Y.; Huigens III, R. W. “Halogenated Quinolines Discovered Through Reductive Amination with Potent Eradication Activities against MRSA, MRSE and VRE Biofilms.” Org. Biomol. Chem., 2015, 13, 10290-10294. 2015 Hot Articles in Organic and Biomolecular Chemistry
- Abouelhassan, Y.; Garrison, A. T.; Bai, F.; Norwood IV, V. M.; Nguyen, M.; Jin, S.; Huigens III, R. W. “A Phytochemical-Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria” ChemMedChem, 2015, 10, 1157-1162.
- Garrison, A. T.; Bai, F.; Abouelhassan, Y.; Paciaroni, N. G.; Jin, S.; Huigens III, R.W. “Bromophenazine Derivatives with Potent Inhibition, Dispersion and Eradication Activities against Staphylococcus aureus Biofilms.” RSC Adv. 2015, 5, 1120-1124.
- Abouelhassan, Y.; Garrison, A. T.; Burch, G. M.; Wong, W.; Norwood IV, V. M.; Huigens III, R. W. “Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategy.” Bioorg. Med. Chem. Lett., 2014, 24, 5076-5080.
- Borrero, N.V.; Bai, F.; Perez, C.; Duong, B.Q.; Rocca, J.R.; Jin, S.; Huigens III, R.W. “Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis.” Org. Biomol. Chem. 2014, 12, 881-886.