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Mirjam N. Trame, Pharm.D., Ph.D.

Mirjam N. Trame

Assistant Professor

Pharmaceutics

OFFICE: 6550 Sanger Road, Room 471

EMAIL: mtrame@cop.ufl.edu

PHONE: 407-313-7052

CV: Link to CV

 

Education

  • Ph.D. Clinical Pharmacy, Westfälische Wilhelms-Universität, Münster, Germany, 2011
  • Pharm.D., University of Florida, Gainesville, FL, USA, 2010
  • Degree in Pharmacy, Westfälische Wilhelms-Universität, Münster, Germany, 2007

Biographical Sketch

Dr. Trame joined the University of Florida as an Assistant Professor at the Center for Pharmacometrics and Systems Pharmacology in Lake Nona (Orlando) in May 2014. She in addition holds an Adjunct Associate Investigator appointment at the Translational Research Institute for Metabolism and Diabetes at Florida Hospital, Orlando where she studies the complex mechanism regulating macronutrient metabolism, body composition and energy expenditure using mathematical modeling.

Besides the human metabolism studies, Dr. Trame’s research focuses in particular on drug safety leveraging post-marketing surveillance data using a systems approach to understand the mechanistic nature of drug-adverse drug reaction pairs on the target and molecular level. Additional research areas concentrate on i) the application of quantitative analysis tools (pharmacometrics, PBPK and quantitative systems pharmacology) to address clinically relevant research questions in the area of diabetes, obesity, energy metabolism related to different diseases, antithrombotic therapy, neurodegenerative diseases, rare diseases, drug induced nephrotoxicity, pediatrics, cardiovascular, cystic fibrosis, and translational research and ii) studying metabolomics to identify early and novel biomarkers to help understand and predict disease progression as well as drug-induced toxicities.

She received her B.S. in Pharmaceutical Sciences from the Westfälische-Wilhelms Universität in Münster, Germany in 2006 and her license to practice as a pharmacist in Germany in 2007. In addition, she earned her Pharm.D. degree from the University of Florida in 2010 and her Ph.D. in Clinical Pharmacology and Pharmacometrics from the Westfälische-Wilhelms Universität in Münster, Germany in 2011. During her Ph.D., she modeled data regarding Therapeutic Drug Monitoring of drugs used in pediatric oncology, focusing on Busulfan, Dimethylacetamide, and Enoxaparin for treatment individualization.

After she received her Ph.D., she completed a 2 year postdoctoral fellowship under the supervision of Prof. Mats Karlsson and Prof. Lena Friberg in the Pharmacometrics Research Group at Uppsala University in Sweden where she focused on PK/PD modeling and simulation of Therapeutic Drug Monitoring (TDM) data in various disease areas (i.e. Anticoagulation, HIV, COPD). In addition, she modeled data from Phase I clinical studies regarding QT prolongation to be used for decision making during clinical drug development for which she was awarded for with the ACoP 2013 Trainee Award to predict potential QT liability based on Phase I dECG data.

Affiliations

Board Member, International Society of Pharmacometrics (ISOP)
Member, ACoP Planning Committee, Program chair elect for AcoP6 and Program chair for ACoP7
Member, International Society for the Study of Xenobiotics (ISSX), ISSX 2015 Planning and Abstract Committee
Member, American Association of Pharmaceutical Scientists (AAPS)
Member, AAPS Pharmacometrics focus group steering committee
Member, American Association for the Advancement of Science (AAAS)
Member, American College of Clinical Pharmacology (ACCP)
Member, American Society for Clinical Pharmacology Therapeutics (ASCPT)
Member, Society for Mathematical Biology (SMB)

Recent Publications

Quantitative Systems Pharmacology Model to Predict the Effects of Commonly Used Anticoagulants on the Human Coagulation Network.

Improving drug safety with a systems pharmacology approach.

Systems pharmacology to predict drug safety in drug development.

MatVPC: A User-friendly Matlab Tool for the Automatic Construction of Visual Predictive Checks and Quantified Visual Predictive Checks of Systems Pharmacology Models
(Link to software: http://sourceforge.net/projects/matvpc/)

Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models