Margaret O. James, Ph.D.

Margaret O. James

Jack C. Massey Professor

Medicinal Chemistry

OFFICE: Medical Science Building, P-629

EMAIL: mojames@ufl.edu

PHONE: 352 273 7707

CV: Link to CV

 

Education

  • B.Sc. Chemistry, University College London, 1969
  • Ph.D. Organic Chemistry, St. Mary’s Medical School, University of London, 1972
  • Post-doctoral fellow, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 1972-75
  • D.Sc. University of London, 1993

Biographical Sketch

Margaret James, Ph.D., investigates factors affecting the metabolism and toxicity of drugs and other xenobiotics in humans and animal species, including aquatic species. She was chosen as the Jack C Massey Professor of Pharmacy in 2006, and as a University of Florida Research Foundation Professor, 1997-2000. Her laboratory studies mechanisms of uptake, biotransformation, excretion and toxicity of xenobiotics, especially environmental chemicals. Dr. James also investigates the influence of xenobiotics on the metabolism of steroid hormones.

Affiliations

Editorial Board, Chemico-Biological Interactions, 2002-present

American Association for the Advancement of Science, Fellow, elected 2011

Editorial Board, Drug Metabolism and Disposition, 1993-present

Editorial Board, Aquatic Toxicology 1991-present

Research Areas

Publications

Representative

James, M.O. and Stacpoole, P.W. Pharmacogenetic considerations with dichloroacetate dosing. Pharmacogenomics, 17(7):743-53, 2016 PMID: 27143230

James, M.O. and Ambadapadi, S. Interactions of cytosolic sulfotransferases with xenobiotics. Drug Metabolism Reviews 45(4):401-414,2013. PMID: 24188364

Li, W., Gu, Y., James, M.O., Hines, R.N., Simpson, P. Langaee, T. and Stacpoole, P.W. Prenatal and postnatal expression of glutathione transferase zeta 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate. Drug Metabolism and Disposition, 40, 232-239, 2012.   PMID 22028317

James, M.O., Marth, C.J. and Rowland-Faux, L. Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine. Aquatic Toxicology 124-125: 72-82, 2012 PMID 22926334

James, MO, Li, W, Summerlot, D, Rowland-Faux, L. and Wood CE “Triclosan is a potent inhibitor of estradiol and estrone sulfonation in sheep placenta”. Environment International, 36: 942-949, 2010 doi:10.1016/j.envint.2009.02.004.

For further information on my publications (except for book chapters) please see my full bibliography.