Jenny Wilkerson, Ph.D.

Jenny Wilkerson

Research Assistant Professor

Pharmacodynamics

OFFICE: MSB P1-31

EMAIL: jenny.wilkerson@cop.ufl.edu

PHONE: 352-294-8908

CV: Link to CV

 

Education

  • Ph.D. Biomedical Sciences, University of New Mexico
  • B.S. Cell/Molecular Biology, Northwest Missouri State University

Biographical Sketch

Jenny Wilkerson, Ph.D., joined the University of Florida College of Pharmacy in November 2017 as a research assistant professor in the department of pharmacodynamics. Wilkerson received her Bachelor of Science degree in cellular/ molecular biology, with a minor in chemistry, from Northwest Missouri State University, and her Ph.D. in biomedical sciences from the University of New Mexico School of Medicine’s department of neurosciences. Upon completion of her doctoral studies, Wilkerson completed a postdoctoral fellowship at Virginia Commonwealth University in the department of pharmacology and toxicology, where she was the recipient for the competitive Ruth L. Kirschstein F32 Individual National Research Service Award. Her research interests broadly encompass the involvement of the immune system in preclinical models of pathological pain and neurodegeneration, with an emphasis on endogenous cannabinoid (endocannabinoid) system modulation. Additionally, an area of keen interest of Wilkerson’s is the examination of the adjunct administration of experimental preclinical compounds to produce enhanced analgesic opioid effects, with diminished drug abuse liability.

Publications

Wilkerson, J.L.; Donvito, G.; Grim, T.W.; Mason, B.L.; Morales, A.; Abdullah, R.A.; Ogasawara, D.; Cravatt, B.F.; and Lichtman, A.H. (2017). Investigation of Diacylglycerol Lipase Alpha Inhibition in the LPS Model of Inflammatory Pain in Mice. J Pharmacol Exp Ther. PMID: 28970359

Donvito, G.; Nass, S.; Wilkerson, J.L.; Curry, Z.A.; Sherman, L.; Kinsey, S.; and Lichtman, A.H. (2017). The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain. Neuropsychopharmacology. PMID: 28857069

Wilkerson, J.L.; Ghosh, S.; Mustafa, M.A.; Abdullah, R.A.; Cabrera, R; Maldonado, R.L.; Cravatt, B.F.; and Lichtman, A.H. (2017) The Endocannabinoid Hydrolysis Inhibitor SA-57 Augments the Antinociceptive Effects of Morphine and Reduces Heroin Seeking Behavior in Mice. Neuropharmacology 114:156-167. PMID: 27890602

Donvito, G.; Wilkerson, J.L.; Damaj, M.I.; and Lichtman, A.H. (2016) Palmitoylethanolamide reverses paclitaxel-induced allodynia in mice. J Pharmacol Exp Ther 359(2):310-318. PMID: 27608657

Bagdas, D.†; Wilkerson, J.L.†; Kulkarni, A.; Toma, W.; AlSharari, S.; Gul, Z.; Lichtman, A.; Papke, R.; Thakur, G.; and Damaj, M.I. (2016) The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain. Br J Pharmacol 173(16):2506-2520. PMID: 27243753

Wilkerson, J.L.; Ghosh, S.; Bagdas, D.; Mason, B.L.; Crowe, M.S.; Hsu, K.L.; Wise, L.E.; Kinsey, S.G.; Damaj, M.I.; Cravatt, B.F.; and Lichtman, A.H. (2016) Diacylglycerol lipase beta inhibition reverses nociceptive behavior in mouse models of inflammatory and neuropathic pain. Br J Pharmacol 173(10):1678-1692. PMID: 26915789

Wilkerson, J.L.; Niphakis, M.J.; Grim, T.W.; Mustafa, M.A.; Abdullah, R.A.; Dewey, W.L.; Akbarali, H.; Banks, M.L.; Wise, L.E.; Cravatt, B.F.; and Lichtman, A.H. (2016) Monoacylglycerol lipase inhibition produces opioid sparing effects in a mouse model of neuropathic pain. J Pharmacol Exp Ther 357(1):145-56. PMID: 26791602

Mukhopadhyay, P.; Baggelaar, M.; Erdelyi, K.; Cao, Z.; Cinar, R.; Fezza, F.; Ignatowska-Janlowska, B; Wilkerson, J.; van Gils, N.; Hansen, T.; Ruben, M.; Soethoudt, M.; Heitman, L.; Kunos, G.; Maccarrone, M.; Lichtman, A.; Pacher, P.; van der Stelt, M. (2016) The novel, orally available and peripherally restricted selective cannabinoid CB2-receptor partial agonist LEI-101 prevents cisplatin-induced nephrotoxicity. Br J Pharmacol 173(3):446-58. PMID: 26398481

Ignatowska-Jankowska, B.†; Wilkerson, J.L.†, Mustafa M.; Abdullah R.; Niphakis M.; Wiley J.L.; Cravatt, B.F.; and Lichtman, A.H. (2015) Selective monoacylglycerol lipase inhibitors: Antinociceptive vs. cannabimimetic effects in mice. J Pharmacol Exp Ther 353:424-432. PMID:25762694

Dengler, E.C.; Alberti, L.B.; Bowman, B.N.; Kerwin, A.A.; Wilkerson, J.L; Moezzi D.R.; Limanovich E.; Wallace, J.A.; Milligan, E.D. (2014) Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain. Journal of Neuroinflammation 11:92 1-21. PMID: 24884664

Dengler, E.C.; Kerwin, A.A.; Liu, J.; Torres, S., Olcott C.M.; Bowman, B.N.; Armijo, L.M.; Gentry, K.R.; Wilkerson, J.; Wallace, J.A.; Jiang, X.; Carnes, E.C.; Brinker C.J.; Milligan, E.D. (2013) Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord. Journal of Controlled Release 168: 209-224. PMID: 23517784

Wilkerson, J.L.; Gentry, K.R.; Dengler, E.C.; Wallace, J.A.; Kerwin, A.A.; Kuhn, M.N.; Alberti, L.B.; Armijo, L.M.; Thakur, G.A.; Makriyannis, A.; Milligan, E.D. (2012) Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokines. Pain 153: 1091-1106. PMID: 22425445

Wilkerson, J.L.; Gentry, K.R.; Dengler, E.C.; Wallace, J.A.; Kerwin, A.A.; Alberti, L.B.; Thakur, G.A.; Makriyannis, A.; Milligan, E.D. (2012) Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia. Brain and Behavior 2: 155–177. PMID: 22574283

Wilkerson, J.L.; Milligan, E.D. (2011) The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief. ISRN Anesthesiology 2011: 1-19. PMID: 22442754