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Jane V. Aldrich, Ph.D.

Jane V. Aldrich

Professor

Medicinal Chemistry

OFFICE: Medical Science Building, P4-27

EMAIL: jaldrich@cop.ufl.edu

PHONE: 352-273-8708

CV: Link to CV

 

Education

  • Ph.D., Interdepartmental Program in Medicinal Chemistry, University of Michigan
  • B.S., Biochemistry, Michigan State University

Biographical Sketch

Jane Aldrich, Ph.D., joined the College of Pharmacy as a professor of medicinal chemistry. She came to the University of Florida from the University of Kansas, where she had been a professor since 2001. She received her Ph.D. from the University of Michigan and completed an NIH postdoctoral fellowship at the University of Minnesota.

The focus of research in her laboratory is the design and synthesis of peptides and peptidomimetic analogs. This research involves examining structure-activity relationships, primarily of opioid peptides, and exploring synthetic methodologies to prepare novel peptide and peptidomimetic analogs. Her research has expanded to also include studies related to drug development, examining the metabolic stability of peptides, their ability to cross biological barriers, and their pharmacokinetic and pharmacological properties in animal models. Current projects focus on novel peptide analogs as potential treatments for drug abuse, pain and cancer.

Affiliations

  • American Chemical Society, Medicinal Chemistry, Organic Chemistry and Biological Chemistry Divisions
  • American Peptide Society
  • Phi Kappa Phi Honor Society
  • Rho Chi Honor Society

Research Interests

  • Drug discovery and development
  • Peptide chemistry

Select Publications

J. V. Aldrich, S. N. Senadheera, N. C. Ross, K.A. Reilley, M. L. Ganno, S. E. Eans, T. F. Murray, and J. P. McLaughlin, “Alanine Analogs of [D-Trp]CJ-15,208: Novel Opioid Activity Profiles and Prevention of Drug- and Stress-Induced Reinstatement of Cocaine-Seeking Behavior,” Br. J. Pharmacol. 2014, 171, 3212-3222.

K. M. DiMattio, T. V. Yakovleva, J. V. Aldrich, A. Cowan and L. Y. Liu-Chen, “Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice,” Neuroscience Lett., 2014, 563C, 155-159.

Archana Mukhopadhyay, Kayann Tabanor, Rathnam and Jane V. Aldrich, “Targeting Inhibitor of Protein Phosphatase 2A as a Therapeutic Strategy for Prostate Cancer Treatment,” Cancer Biol. Ther. 2013, 14, 962-972.

Shainnel O. Eans, Michelle L. Ganno, Kate J. Reilley, Kshitij A. Patkar, Sanjeewa N.Senadheera, Jane V. Aldrich and Jay P. McLaughlin, “The macrocyclic tetrapeptide [DTrp]CJ-15,208 produces short acting κ opioid receptor antagonism in the CNS after oral administration,” Br. J. Pharmacol. 2013, 169, 426-436.

Yan Zhou, Francesco Leri,, Stephanie Grella, Jane V. Aldrich, and Mary Jeanne Kreek, “Involvement of dynorphin and kappa opioid receptor in stress-induced reinstatement of heroin seeking in rats,” Synapse 2013, 67, 358-361.

Jane V. Aldrich, Sanjeewa N. Senadheera, Nicolette C. Ross, Michelle L. Ganno, Shainnel O. Eans, and Jay P. McLaughlin, “The macrocyclic peptide natural product CJ-15,208 isorally active and prevents reinstatement of extinguished cocaine seeking behavior,” J. Nat. Prod. 2013, 76, 433-438.

Nicolette C. Ross, Kate J. Reilley, Thomas F. Murray, Jane V. Aldrich, and Jay P. McLaughlin, Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting kappa opioid receptor antagonism, Br. J. Pharmacol. 2012, 165, 1097-1108.

Jane V. Aldrich, Santosh S. Kulkarni, Sanjeewa N. Senadheera, Nicolette C. Ross, Kate J. Reilley, Shainnel Eans, Michelle L. Ganno, Thomas F. Murray, and Jay P. McLaughlin, “Unexpected Opioid Activity Profiles of Analogs of the Novel Peptide Kappa Opioid Receptor Ligand CJ-15,208,” ChemMedChem 2011, 6, 1739–1745.

Nicolette C. Ross, Santosh S. Kulkarni, Jay P. McLaughlin and Jane V. Aldrich, “Synthesis of CJ-15,208, a novel-opioid receptor antagonist, Tetrahedron Lett. 2010, 51, 5020-5023.

J. V. Aldrich, Kshitij A. Patkar, and Jay P. McLaughlin, “Zyklophin, a systemically active selective kappa opioid peptide receptor antagonist with short duration of action,” Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 18396-18401.

Bhaswati Sinha, Zhengyu Cao, Thomas F. Murray and Jane V. Aldrich, “Discovery of Dermorphin-Based Affinity Labels with Subnanomolar Affinity for Mu Opioid Receptors, J. Med. Chem. 2009, 52, 7372–7375.

Jane V. Aldrich, Vivek Kumar, Thomas F. Murray, Wei Guang, and Jia Bei Wang, “Dual Labeled Peptides as Tools to Study Receptors: Nanomolar Affinity Derivatives of TIPP (Tyr-Tic-Phe-Phe) as Probes of Opioid Receptors,” Bioconj. Chem. 2009, 20, 201-204.