Bonnie A. Avery, Ph.D.

Bonnie A. Avery

Clinical Professor

Pharmaceutics

EMAIL: bavery@cop.ufl.edu

 

Education

  • Ph.D., University of North Dakota
  • B.S., Minot State University
  • B.A., Minot State University

Biographical Sketch

Bonnie A. Avery, Ph.D., joined the College of Pharmacy as a clinical professor of pharmaceutics in January 2017. In general, she is a broadly trained analytical chemist whose research focuses in the areas of physical pharmaceutics, analytical method development and validation and pre-clinical pharmacokinetics. For over 20 years, the majority of her research has centered on novel compound method development and validation. Within the past 10 years, she has extended the boundaries of her research to include pre-clinical pharmacokinetics. She has developed skills in areas including, but not limited to, basic in vivo pharmacokinetic studies in rats and mice, in vitro liver microsomal stability, in situ liver perfusion assays, protein binding, determination of blood/brain ratios, Pgp studies and drug tissue accumulation studies. In collaboration with groups in medicinal chemistry and natural product drug discovery, she has successfully managed pharmacokinetic research on over 50 novel compounds including antimalarials, neuropeptide FF ligands, opioid ligands, sigma receptor ligand/probes and anticancer compounds. She has successfully garnered contract pharmacokinetic research from various companies on drugs such as a paclitaxel pro-drug, synthetic thiazolidinedione, CoQ10, nicotinamide riboside and novel epothilone D analogs. In addition to her personal research interests, she serves as the laboratory director of the UF Translational Drug Development Core.

Affiliations

  • Laboratory Director, UF Translational Drug Development Core
  • Vice Chair, APQ section, American Association of Pharmaceutical Scientists (AAPS)
  • Board of Directors, AAPS Foundation
  • American Association of Colleges of Pharmacy
  • American Chemical Society
  • International Narcotics Research Conference
  • International Cannabinoid Research Society

Research Interests

  • Drug abuse and addiction
  • Pain
  • Pre-clinical pharmacokinetics
  • Drug development

Select Publications

Quantification of Highly Selective Sigma-1 Receptor Antagonist CM304 using Liquid Chromatography Tandem Mass Spectrometry and its application to a Pre-clinical Pharmacokinetic Study.
Avery BA, Vuppala PK, Jamalapuram S, Sharma A, Mesangeau C, Chin FT, McCurdy CR. Drug Test Anal. 2016 Dec 30. doi: 10.1002/dta.2156. [Epub ahead of print] PMID: 28039926

Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine.
Lydecker AG, Sharma A, McCurdy CR, Avery BA, Babu KM, Boyer EW. J Med Toxicol. 2016 Dec;12(4):341-349. PMID: 27752985

Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET.
James ML, Shen B, Nielsen CH, Behera D, Buckmaster CL, Mesangeau C, Zavaleta C, Vuppala PK, Jamalapuram S, Avery BA, Lyons DM, McCurdy CR, Biswal S, Gambhir SS, Chin FT. J Nucl Med. 2014 Jan;55(1):147-53. doi: 10.2967/jnumed.113.120261. PMID: 24337599 Free PMC Article

Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study.
Vuppala PK, Jamalapuram S, Furr EB, McCurdy CR, Avery BA. Biomed Chromatogr. 2013 Dec;27(12):1726-32. doi: 10.1002/bmc.2986. PMID: 23893615 Free PMC Article

Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics.
Jamalapuram S, Vuppala PK, Abdelazeem AH, McCurdy CR, Avery BA. Biomed Chromatogr. 2013 Aug;27(8):1034-40. doi: 10.1002/bmc.2901. PMID: 23558564 Free PMC Article

New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects.
James ML, Shen B, Zavaleta CL, Nielsen CH, Mesangeau C, Vuppala PK, Chan C, Avery BA, Fishback JA, Matsumoto RR, Gambhir SS, McCurdy CR, Chin FT. J Med Chem. 2012 Oct 11;55(19):8272-82. doi: 10.1021/jm300371c. PMID: 22853801 Free PMC Article

Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study.
Jamalapuram S, Vuppala PK, Mesangeau C, McCurdy CR, Avery BA. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:1-6. doi: 10.1016/j.jchromb.2011.12.013. PMID: 22406103 Free PMC Article

Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics.
Pabbisetty D, Illendula A, Muraleedharan KM, Chittiboyina AG, Williamson JS, Avery MA, Avery BA. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:123-9. doi: 10.1016/j.jchromb.2012.02.007. PMID: 22365535

Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine.
Seminerio MJ, Robson MJ, Abdelazeem AH, Mesangeau C, Jamalapuram S, Avery BA, McCurdy CR, Matsumoto RR. AAPS J. 2012 Mar;14(1):43-51. doi: 10.1208/s12248-011-9311-8. PMID: 22183188 Free PMC Article

Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents.
Kaushal N, Robson MJ, Vinnakota H, Narayanan S, Avery BA, McCurdy CR, Matsumoto RR. AAPS J. 2011 Sep;13(3):336-46. doi: 10.1208/s12248-011-9274-9. PMID: 21494909 Free PMC Article